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• W2094998417 abstract "Human low-density lipoprotein (LDL) was labelled with the excimeric fluorescent phospholipid analogue 1-palmitoyl-2-(1′-pyreneoctanoyl)-sn-glycero-3-phosphocholine by using phosphatidylcholine-specific transfer protein for the probe insertion. The lateral diffusivity of the probe in the phospholipid/cholesterol surface monolayer of LDL was determined from the measured dependence of the pyrene monomer fluorescence yield on probe concentration. The data were analyzed by the milling-crowd model [J. Eisinger et al. (1986) Biophys. J. 49, 987–1001] to obtain the short-range lateral diffusivity of the probe. The lateral mobility of the probe in LDL was compared to that in model lipid systems, i.e. in protein-free LDL-like lipid particles and in small unilamellar vesicles, with a phospholipid/cholesterol composition characteristic of LDL. This analysis with the probability PE= 1 for excimer production between nearest-neighbour probes gives the lower limits for f, the frequency of translational lipid–lipid exchanges of the probe of 0.62 × 108, 0.19 × 108 and 0.19 × 108 s−1 in LDL, LDL-like lipid particles, and small unilamellar vesicles, respectively. The lower limits for the corresponding lateral diffusion constants are 16, 5 and 5 μm2 s−1. The results suggest that the translational mobility of phospholipid molecules in the lipid–protein surface of LDL is not constrained by the apolipoprotein B-100 moiety or the neutral lipid core of the lipoprotein. Instead, the protein moiety may perturb the lipid order with the lipid–associating peptide domains and thus fluidize the amphiphilic surface monolayer of LDL relative to the protein-free model systems. In general, lateral diffusivity of the pyrenyl phospholipid probe in LDL and the model lipid systems is comparable to the lateral mobility of lipid analogue probes in a variety of model and biological membranes." @default.
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• W2094998417 date "1989-12-01" @default.
• W2094998417 modified "2023-10-13" @default.
• W2094998417 title "Lateral diffusion of phospholipids in the lipid surface of human low-density lipoprotein measured with a pyrenyl phospholipid probe" @default.
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• W2094998417 doi "https://doi.org/10.1111/j.1432-1033.1989.tb15230.x" @default.
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