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• W2095004825 startingPage "341" @default.
• W2095004825 abstract "Desmin, the main intermediate filament (IF) protein in skeletal and heart muscle cells, is of great importance as a part of the cytoskeleton. The IFs surround and interlink myofibrils, and connect the peripheral myofibrils with the sarcolemma. In myotendinous junctions and neuromuscular junctions of skeletal muscle fibres, desmin is enriched. In the heart, desmin is increased at intercalated discs, the attachment between cardiomyocytes, and it is the main component in Purkinje fibres of the conduction system. Desmin is the first muscle-specific protein to appear during myogenesis. Nevertheless, lack of desmin, as shown from experiments with desmin knockout (K/O) mice, does not influence myogenesis or myofibrillogenesis. However, the desmin knock-out mice postnatally develop a cardiomyopathy and a muscle dystrophy in highly used skeletal muscles. In other skeletal muscles the organization of myofibrils is remarkably unaffected. Thus, the main consequence of the lack of desmin is that the muscle fibres become more susceptible to damage. The loss of membrane integrity leads to a dystrophic process, with degeneration and fibrosis. In the heart cardiac failure develops, whereas in affected skeletal muscles regenerative attempts are seen. In humans, accumulations of desmin have been a hallmark for presumptive desmin myopathies. Recent investigations have shown that some families with such a myopathy have a defect in the gene coding for alphaB-crystallin, whereas others have mutations in the desmin gene. Typical features of these patients are cardiac affections and muscle weakness. Thus, mutations in the desmin gene is pathogenic for a distinct type of muscle disorder." @default.
• W2095004825 created "2016-06-24" @default.
• W2095004825 creator A5051110265 @default.
• W2095004825 creator A5054375041 @default.
• W2095004825 date "2001-03-01" @default.
• W2095004825 modified "2023-10-18" @default.
• W2095004825 title "Desmin-related myopathies in mice and man" @default.
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• W2095004825 cites W1565633801 @default.
• W2095004825 cites W1604252033 @default.
• W2095004825 cites W1608141030 @default.
• W2095004825 cites W1965336601 @default.
• W2095004825 cites W1969467903 @default.
• W2095004825 cites W1971584765 @default.
• W2095004825 cites W1975393846 @default.
• W2095004825 cites W1977869838 @default.
• W2095004825 cites W1984776494 @default.
• W2095004825 cites W1986632434 @default.
• W2095004825 cites W1991875866 @default.
• W2095004825 cites W1992542653 @default.
• W2095004825 cites W1993955896 @default.
• W2095004825 cites W2000732040 @default.
• W2095004825 cites W2003036450 @default.
• W2095004825 cites W2003654592 @default.
• W2095004825 cites W2006225310 @default.
• W2095004825 cites W2007699535 @default.
• W2095004825 cites W2016716219 @default.
• W2095004825 cites W2017912935 @default.
• W2095004825 cites W2021698963 @default.
• W2095004825 cites W2027745468 @default.
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• W2095004825 cites W2032625271 @default.
• W2095004825 cites W2035771990 @default.
• W2095004825 cites W2038064537 @default.
• W2095004825 cites W2044157569 @default.
• W2095004825 cites W2044510502 @default.
• W2095004825 cites W2046756882 @default.
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• W2095004825 cites W2068980157 @default.
• W2095004825 cites W2070280831 @default.
• W2095004825 cites W2073122268 @default.
• W2095004825 cites W2074683474 @default.
• W2095004825 cites W2077603415 @default.
• W2095004825 cites W2081803633 @default.
• W2095004825 cites W2083887563 @default.
• W2095004825 cites W2084386191 @default.
• W2095004825 cites W2087905663 @default.
• W2095004825 cites W2093377166 @default.
• W2095004825 cites W2094783888 @default.
• W2095004825 cites W2104555172 @default.
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• W2095004825 cites W2109847142 @default.
• W2095004825 cites W2111912537 @default.
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• W2095004825 cites W2119932131 @default.
• W2095004825 cites W2122412289 @default.
• W2095004825 cites W2124021558 @default.
• W2095004825 cites W2131321439 @default.
• W2095004825 cites W2146814457 @default.
• W2095004825 cites W2148133676 @default.
• W2095004825 cites W2152351059 @default.
• W2095004825 cites W2152438236 @default.
• W2095004825 cites W2153567613 @default.
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• W2095004825 cites W2157479429 @default.
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• W2095004825 doi "https://doi.org/10.1046/j.1365-201x.2001.00837.x" @default.
• W2095004825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11412147" @default.
• W2095004825 hasPublicationYear "2001" @default.
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