FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095016306> ?p ?o ?g. }

• W2095016306 endingPage "47" @default.
• W2095016306 startingPage "39" @default.
• W2095016306 abstract "Interdisciplinary research at the interface of polymer chemistry and the biomedical sciences has produced the first polymer-based nanomedicines for the diagnosis and treatment of cancer. These water-soluble hybrid constructs, designed for intravenous administration, fall into two main categories: polymer–protein conjugates or polymer–drug conjugates. Polymer conjugation to proteins reduces immunogenicity, prolongs plasma half-life and enhances protein stability. Polymer–drug conjugation promotes tumor targeting through the enhanced permeability and retention (EPR) effect and, at the cellular level following endocytic capture, allows lysosomotropic drug delivery. The successful clinical application of polymer–protein conjugates (PEGylated enzymes and cytokines) and promising results arising from clinical trials with polymer-bound chemotherapy (e.g. doxorubicin, paclitaxel, camptothecins) has provided a firm foundation for more sophisticated second-generation constructs that deliver the newly emerging target-directed anticancer agents (e.g. modulators of the cell cycle, signal transduction inhibitors and antiangiogenic drugs) in addition to polymer–drug combinations (e.g. endocrine- and chemo-therapy). Interdisciplinary research at the interface of polymer chemistry and the biomedical sciences has produced the first polymer-based nanomedicines for the diagnosis and treatment of cancer. These water-soluble hybrid constructs, designed for intravenous administration, fall into two main categories: polymer–protein conjugates or polymer–drug conjugates. Polymer conjugation to proteins reduces immunogenicity, prolongs plasma half-life and enhances protein stability. Polymer–drug conjugation promotes tumor targeting through the enhanced permeability and retention (EPR) effect and, at the cellular level following endocytic capture, allows lysosomotropic drug delivery. The successful clinical application of polymer–protein conjugates (PEGylated enzymes and cytokines) and promising results arising from clinical trials with polymer-bound chemotherapy (e.g. doxorubicin, paclitaxel, camptothecins) has provided a firm foundation for more sophisticated second-generation constructs that deliver the newly emerging target-directed anticancer agents (e.g. modulators of the cell cycle, signal transduction inhibitors and antiangiogenic drugs) in addition to polymer–drug combinations (e.g. endocrine- and chemo-therapy)." @default.
• W2095016306 created "2016-06-24" @default.
• W2095016306 creator A5040979364 @default.
• W2095016306 creator A5083919487 @default.
• W2095016306 date "2006-01-01" @default.
• W2095016306 modified "2023-10-17" @default.
• W2095016306 title "Polymer conjugates: nanosized medicines for treating cancer" @default.
• W2095016306 cites W10640494 @default.
• W2095016306 cites W1520735777 @default.
• W2095016306 cites W1578375703 @default.
• W2095016306 cites W1579495761 @default.
• W2095016306 cites W1583405960 @default.
• W2095016306 cites W1608878503 @default.
• W2095016306 cites W1967708299 @default.
• W2095016306 cites W1969843553 @default.
• W2095016306 cites W1975429911 @default.
• W2095016306 cites W1977161245 @default.
• W2095016306 cites W1977339499 @default.
• W2095016306 cites W1978183755 @default.
• W2095016306 cites W1989067119 @default.
• W2095016306 cites W2002520870 @default.
• W2095016306 cites W2007879491 @default.
• W2095016306 cites W2022234371 @default.
• W2095016306 cites W2022776423 @default.
• W2095016306 cites W2024350017 @default.
• W2095016306 cites W2027959934 @default.
• W2095016306 cites W2029245342 @default.
• W2095016306 cites W2030855909 @default.
• W2095016306 cites W2035715457 @default.
• W2095016306 cites W2036570425 @default.
• W2095016306 cites W2037808957 @default.
• W2095016306 cites W2040426912 @default.
• W2095016306 cites W2041759339 @default.
• W2095016306 cites W2042295385 @default.
• W2095016306 cites W2044030495 @default.
• W2095016306 cites W2054064585 @default.
• W2095016306 cites W2054565831 @default.
• W2095016306 cites W2060571466 @default.
• W2095016306 cites W2061510929 @default.
• W2095016306 cites W2064225223 @default.
• W2095016306 cites W2064763096 @default.
• W2095016306 cites W2072238569 @default.
• W2095016306 cites W2078263947 @default.
• W2095016306 cites W2080645360 @default.
• W2095016306 cites W2086010040 @default.
• W2095016306 cites W2087915477 @default.
• W2095016306 cites W2092554451 @default.
• W2095016306 cites W2094964650 @default.
• W2095016306 cites W2098279377 @default.
• W2095016306 cites W2103722820 @default.
• W2095016306 cites W2115533803 @default.
• W2095016306 cites W2119405093 @default.
• W2095016306 cites W2135877955 @default.
• W2095016306 cites W2141743126 @default.
• W2095016306 cites W2144498681 @default.
• W2095016306 cites W2146531326 @default.
• W2095016306 cites W2152037201 @default.
• W2095016306 cites W2158774273 @default.
• W2095016306 cites W2163757114 @default.
• W2095016306 cites W2164788594 @default.
• W2095016306 cites W2165390726 @default.
• W2095016306 cites W2193875839 @default.
• W2095016306 cites W223294073 @default.
• W2095016306 cites W2240322050 @default.
• W2095016306 cites W2249531032 @default.
• W2095016306 cites W2280188632 @default.
• W2095016306 cites W2303578527 @default.
• W2095016306 cites W2304933747 @default.
• W2095016306 cites W2317933941 @default.
• W2095016306 cites W2590416822 @default.
• W2095016306 cites W4233820214 @default.
• W2095016306 cites W4239173096 @default.
• W2095016306 cites W4241689822 @default.
• W2095016306 cites W4247783017 @default.
• W2095016306 cites W4297604829 @default.
• W2095016306 cites W88079597 @default.
• W2095016306 cites W99710948 @default.
• W2095016306 doi "https://doi.org/10.1016/j.tibtech.2005.11.006" @default.
• W2095016306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16307811" @default.
• W2095016306 hasPublicationYear "2006" @default.
• W2095016306 type Work @default.
• W2095016306 sameAs 2095016306 @default.
• W2095016306 citedByCount "411" @default.
• W2095016306 countsByYear W20950163062012 @default.
• W2095016306 countsByYear W20950163062013 @default.
• W2095016306 countsByYear W20950163062014 @default.
• W2095016306 countsByYear W20950163062015 @default.
• W2095016306 countsByYear W20950163062016 @default.
• W2095016306 countsByYear W20950163062017 @default.
• W2095016306 countsByYear W20950163062018 @default.
• W2095016306 countsByYear W20950163062019 @default.
• W2095016306 countsByYear W20950163062020 @default.
• W2095016306 countsByYear W20950163062021 @default.
• W2095016306 countsByYear W20950163062022 @default.
• W2095016306 countsByYear W20950163062023 @default.
• W2095016306 crossrefType "journal-article" @default.
• W2095016306 hasAuthorship W2095016306A5040979364 @default.
• W2095016306 hasAuthorship W2095016306A5083919487 @default.

• next