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- W2095041765 endingPage "957" @default.
- W2095041765 startingPage "945" @default.
- W2095041765 abstract "Urease is the enzyme that catalyzes the hydrolysis of urea, which is involved in serious infections caused by Helicobacter pylori in the gastric tract, as well as Proteus and related species in the urinary tract. The necessity to treat such infections has stimulated intensive studies on various groups of urease inhibitors.Patent literature on urease inhibitors with possible applications in medicine is reviewed in this paper. Hydroxamic acids, phosphoramidates, urea derivatives, quinones and heterocyclic compounds constitute the major classes of structures with such activity.Until now, only one compound, acetohydroxamic acid, has been clinically used for the treatment of urinary tract infections by urease inhibition. Unfortunately, it exhibits severe side effects. Thus, it seems that the full potential of urease inhibition has not yet been fully explored. Several Japanese patents related to the use of herbal extracts as sources of polyphenolic urease inhibitors have been considered as complementary or alternative therapy; however, their accessibility is quite possibly due to reduced restrictions for the introduction of natural products to the market." @default.
- W2095041765 created "2016-06-24" @default.
- W2095041765 creator A5032822117 @default.
- W2095041765 creator A5063684833 @default.
- W2095041765 date "2011-04-04" @default.
- W2095041765 modified "2023-09-25" @default.
- W2095041765 title "Urease inhibitors as potential drugs for gastric and urinary tract infections: a patent review" @default.
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- W2095041765 doi "https://doi.org/10.1517/13543776.2011.574615" @default.
- W2095041765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21457123" @default.
- W2095041765 hasPublicationYear "2011" @default.