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• W2095061901 abstract "Significance Excessive activation of poly(ADP-ribose) (PAR) polymerase (PARP) is intimately linked to cell death in a variety of organ systems. It has long been thought that the cell death caused by excessive activation of PARP occurs through the catalytic consumption of NAD + followed by reduction of ATP and bioenergetic collapse. This study shows that the bioenergetic collapse is caused not by the consumption of NAD + but by PAR-dependent inhibition of hexokinase activity leading to defects in glycolysis. These results are consistent with the notion that cell death induced by excessive PARP activity (parthanatos) is an active cell-death program that is initiated by PAR signaling." @default.
• W2095061901 created "2016-06-24" @default.
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• W2095061901 date "2014-07-01" @default.
• W2095061901 modified "2023-10-13" @default.
• W2095061901 title "Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis" @default.
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• W2095061901 doi "https://doi.org/10.1073/pnas.1405158111" @default.
• W2095061901 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4104885" @default.
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