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- W2095068941 abstract "Voltage dependent anion channel (VDAC) of mitochondria plays a crucial role in apoptosis. Human VDAC-1, reconstituted in planar lipid bilayer showed reduced conductance when treated with curcumin. Curcumin interacts with residues in the α helical N-terminus of VDAC and in the channel wall, as revealed by molecular docking, followed by mutational analysis. N-terminus mimicking peptide showed conformational changes in circular dichroism, upon curcumin treatment. We propose that the interaction of curcumin with amino acids in N-terminus and in channel wall fixes the α helix in closed conformation. This restricts its movement which is required for the opening of the channel." @default.
- W2095068941 created "2016-06-24" @default.
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- W2095068941 date "2015-01-01" @default.
- W2095068941 modified "2023-10-12" @default.
- W2095068941 title "Modulation of the mitochondrial voltage dependent anion channel (VDAC) by curcumin" @default.
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- W2095068941 doi "https://doi.org/10.1016/j.bbamem.2014.10.014" @default.
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