Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095069903> ?p ?o ?g. }
- W2095069903 endingPage "4060" @default.
- W2095069903 startingPage "4048" @default.
- W2095069903 abstract "In earlier work we have provided evidence for the presence of a subsite within the CB1 and CB2 cannabinoid receptor binding domains of classical cannabinoids. This putative subsite corresponds to substituents on the C1‘-position of the C3-alkyl side chain, a key pharmacophoric feature in this class of compounds. We have now refined this work through the synthesis of additional C1‘-cycloalkyl compounds using newly developed approaches. Our findings indicate that the C1‘-cyclopropyl and C1‘-cyclopentyl groups are optimal pharmacophores for both receptors while the C1‘-cyclobutyl group interacts optimally with CB1 but not with CB2. The C1‘-cyclohexyl analogs have reduced affinities for both CB1 and CB2. However, these affinities are significantly improved with the introduction of a C2‘−C3‘ cis double bond that modifies the available conformational space within the side chain and allows for a better accommodation of a six-membered ring within the side chain subsite. Our SAR results are highlighted by molecular modeling of key analogs." @default.
- W2095069903 created "2016-06-24" @default.
- W2095069903 creator A5000000809 @default.
- W2095069903 creator A5000540926 @default.
- W2095069903 creator A5015044273 @default.
- W2095069903 creator A5046024579 @default.
- W2095069903 creator A5061917163 @default.
- W2095069903 creator A5067521970 @default.
- W2095069903 creator A5082386968 @default.
- W2095069903 creator A5088644120 @default.
- W2095069903 creator A5091722348 @default.
- W2095069903 date "2007-08-01" @default.
- W2095069903 modified "2023-10-11" @default.
- W2095069903 title "C1‘-Cycloalkyl Side Chain Pharmacophore in Tetrahydrocannabinols" @default.
- W2095069903 cites W172430044 @default.
- W2095069903 cites W1974495287 @default.
- W2095069903 cites W1974913185 @default.
- W2095069903 cites W1977390424 @default.
- W2095069903 cites W1984480298 @default.
- W2095069903 cites W1987779865 @default.
- W2095069903 cites W1989073099 @default.
- W2095069903 cites W1990252792 @default.
- W2095069903 cites W1993603030 @default.
- W2095069903 cites W2004508431 @default.
- W2095069903 cites W2008118395 @default.
- W2095069903 cites W2008616334 @default.
- W2095069903 cites W2009018348 @default.
- W2095069903 cites W2014590959 @default.
- W2095069903 cites W2019722378 @default.
- W2095069903 cites W2024653583 @default.
- W2095069903 cites W2031888213 @default.
- W2095069903 cites W2038720497 @default.
- W2095069903 cites W2048123063 @default.
- W2095069903 cites W2056188558 @default.
- W2095069903 cites W2061035616 @default.
- W2095069903 cites W2075894678 @default.
- W2095069903 cites W2080354984 @default.
- W2095069903 cites W2081734305 @default.
- W2095069903 cites W2085741941 @default.
- W2095069903 cites W2092639405 @default.
- W2095069903 cites W2095418258 @default.
- W2095069903 cites W2113095977 @default.
- W2095069903 cites W2116228502 @default.
- W2095069903 cites W2124248227 @default.
- W2095069903 cites W2136046283 @default.
- W2095069903 cites W2146624994 @default.
- W2095069903 cites W2159395686 @default.
- W2095069903 cites W2949855707 @default.
- W2095069903 cites W4238140818 @default.
- W2095069903 cites W95140143 @default.
- W2095069903 doi "https://doi.org/10.1021/jm070121a" @default.
- W2095069903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17672444" @default.
- W2095069903 hasPublicationYear "2007" @default.
- W2095069903 type Work @default.
- W2095069903 sameAs 2095069903 @default.
- W2095069903 citedByCount "45" @default.
- W2095069903 countsByYear W20950699032012 @default.
- W2095069903 countsByYear W20950699032013 @default.
- W2095069903 countsByYear W20950699032014 @default.
- W2095069903 countsByYear W20950699032015 @default.
- W2095069903 countsByYear W20950699032016 @default.
- W2095069903 countsByYear W20950699032017 @default.
- W2095069903 countsByYear W20950699032018 @default.
- W2095069903 countsByYear W20950699032019 @default.
- W2095069903 countsByYear W20950699032020 @default.
- W2095069903 countsByYear W20950699032021 @default.
- W2095069903 countsByYear W20950699032022 @default.
- W2095069903 countsByYear W20950699032023 @default.
- W2095069903 crossrefType "journal-article" @default.
- W2095069903 hasAuthorship W2095069903A5000000809 @default.
- W2095069903 hasAuthorship W2095069903A5000540926 @default.
- W2095069903 hasAuthorship W2095069903A5015044273 @default.
- W2095069903 hasAuthorship W2095069903A5046024579 @default.
- W2095069903 hasAuthorship W2095069903A5061917163 @default.
- W2095069903 hasAuthorship W2095069903A5067521970 @default.
- W2095069903 hasAuthorship W2095069903A5082386968 @default.
- W2095069903 hasAuthorship W2095069903A5088644120 @default.
- W2095069903 hasAuthorship W2095069903A5091722348 @default.
- W2095069903 hasConcept C148001335 @default.
- W2095069903 hasConcept C170493617 @default.
- W2095069903 hasConcept C178790620 @default.
- W2095069903 hasConcept C178910836 @default.
- W2095069903 hasConcept C185592680 @default.
- W2095069903 hasConcept C204921945 @default.
- W2095069903 hasConcept C2778938600 @default.
- W2095069903 hasConcept C2780263894 @default.
- W2095069903 hasConcept C2780283098 @default.
- W2095069903 hasConcept C2780378348 @default.
- W2095069903 hasConcept C521977710 @default.
- W2095069903 hasConcept C55493867 @default.
- W2095069903 hasConcept C56173144 @default.
- W2095069903 hasConcept C71240020 @default.
- W2095069903 hasConceptScore W2095069903C148001335 @default.
- W2095069903 hasConceptScore W2095069903C170493617 @default.
- W2095069903 hasConceptScore W2095069903C178790620 @default.
- W2095069903 hasConceptScore W2095069903C178910836 @default.
- W2095069903 hasConceptScore W2095069903C185592680 @default.
- W2095069903 hasConceptScore W2095069903C204921945 @default.