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- W2095085511 abstract "In general, glutathione conjugation is regarded as a detoxication reaction. However, depending on the properties of the substrate, bioactivation is also possible. Four types of activation reaction have been recognized: direct-acting compounds, conjugates that are activated through cysteine conjugate beta-lyase, conjugates that are activated through redox cycling and lastly conjugates that release the original reactive parent compound. The glutathione S-transferases have three connections with the formation of biactivated conjugates: they catalyze their formation in a number of cases, they are the earliest available target for covalent binding by these conjugates and lastly, the parent alkylating agents are regularly involved in the induction of the enzymes. Individual susceptibility for each of these agents is determined by individual transferase subunit composition and methods are becoming available to assess this susceptibility." @default.
- W2095085511 created "2016-06-24" @default.
- W2095085511 creator A5080235721 @default.
- W2095085511 date "2000-12-01" @default.
- W2095085511 modified "2023-10-14" @default.
- W2095085511 title "Glutathione conjugation as a bioactivation reaction" @default.
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- W2095085511 doi "https://doi.org/10.1016/s0009-2797(00)00214-3" @default.
- W2095085511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11154735" @default.
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