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- W2095098014 abstract "The present study demonstrates a chemometric approach to identify the significant factors influencing the reverse phase high performance liquid chromatography (RP-HPLC) determination of metaxalone in bulk and pharmaceutical dosage forms. The combined effect of buffer pH, % organic phase and flow rate, each at three levels was screened for responses such as retention time, tailing factor and number of theoretical plates. The responses were statistically optimized with the aid of response surface methodology using Box–Behnken experimental design (BBD). Phosphate buffer (pH 5): acetonitrile (41.74: 58.26 v/v) as eluent pumped at 0.8 ml/minflow rate was found to be the optimal condition to attain desired responses. The optimized method was further validated with respect to linearity, precision, accuracy and sensitivity according to the current regulatory requirements. Finally, the developed experimental design was validated by statistical analysis using one-way ANOVA showed that the proposed method was simple, sensitive, robust and represents an improvement over the existing methods for routine analysis of the metaxalone." @default.
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- W2095098014 date "2015-01-28" @default.
- W2095098014 modified "2023-09-27" @default.
- W2095098014 title "RP-HPLC Method for Determination of Metaxalone Using Box- Behnken Experimental Design." @default.
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- W2095098014 doi "https://doi.org/10.14205/2309-4435.2014.02.02.1" @default.
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