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- W2095098889 abstract "Nonalcoholic fatty liver disease (NAFLD) affects up to 30% of the adult population in Western societies, yet the underlying molecular pathways remain poorly understood. Here, we identify the dimeric Activator Protein 1 as a regulator of NAFLD. Fos-related antigen 1 (Fra-1) and Fos-related antigen 2 (Fra-2) prevent dietary NAFLD by inhibiting prosteatotic PPARγ signaling. Moreover, established NAFLD and the associated liver damage can be efficiently reversed by hepatocyte-specific Fra-1 expression. In contrast, c-Fos promotes PPARγ expression, while c-Jun exerts opposing, dimer-dependent functions. Interestingly, JunD was found to be essential for PPARγ signaling and NAFLD development. This unique antagonistic regulation of PPARγ by distinct AP-1 dimers occurs at the transcriptional level and establishes AP-1 as a link between obesity, hepatic lipid metabolism, and NAFLD." @default.
- W2095098889 created "2016-06-24" @default.
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- W2095098889 date "2014-01-01" @default.
- W2095098889 modified "2023-10-15" @default.
- W2095098889 title "Regulation of Steatohepatitis and PPARγ Signaling by Distinct AP-1 Dimers" @default.
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- W2095098889 doi "https://doi.org/10.1016/j.cmet.2013.11.018" @default.
- W2095098889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4023468" @default.
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