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- W2095105178 abstract "We investigated the effects of oxidative stress on mRNA levels of heparin-binding epidermal growth factor-like growth factor (HB-EGF) and amphiregulin (AR) in rat gastric epithelial RGM1 cells. In response to stimulation with hydrogen peroxide (100-400 μM), gene expression of HB-EGF and AR increased in a dose-dependent manner, peaked at 3 h, and returned to the base line at 7 h. Hydrogen peroxide-induced HB-EGF and AR gene expression was blocked by pretreatment with an antioxidant N-acetyl-cysteine. In addition, it was significantly inhibited by pretreatment with EGF receptor-specific tyrphostin AG1478, but not by depletion of protein kinase C. These data indicate that oxidative stress upregulates expression of EGF-related polypeptides and the possible involvement of EGF receptor in this process." @default.
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- W2095105178 date "1996-09-01" @default.
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- W2095105178 title "Oxidative Stress Increases Gene Expression of Heparin-Binding EGF-like Growth Factor and Amphiregulin in Cultured Rat Gastric Epithelial Cells" @default.
- W2095105178 doi "https://doi.org/10.1006/bbrc.1996.1391" @default.
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