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• W2095114372 abstract "PURINORECEPTOR-MEDIATED intracellular Ca2+ release was studied in freshly isolated adult mouse dorsal root ganglia (DRG) neurones. The cytoplasmic Ca2+ concentration ([Ca2+]i) was measured using indo-1-based microfluorimetry. The application of 100 microM ATP in Ca(2+)-free solution triggered an increase in [Ca2+]i in 93% of large DRG neurones but in no small ones. The ATP-induced [Ca2+]i transients in large neurones were inhibited by cells incubation with thapsigargin or by intracellular dialysis with heparin-containing solution. The ATP-triggered increase in [Ca2+]i was not mimicked by adenosine and was blocked by suramin, suggesting the involvement of metabotropic (PZY) purinoreceptors. We conclude that large (proprioceptive) DRG neurones express PZY purinoreceptors linked to the inositol 1,4,5-triphosphate-Ca2+ intracellular signal transduction cascade, whereas small (nociceptive) DRG neurones are devoid of such a mechanism." @default.
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• W2095114372 date "1997-05-01" @default.
• W2095114372 modified "2023-10-14" @default.
• W2095114372 title "ATP induces Ca2+ release from IP3-sensitive Ca2+ stores exclusively in large DRG neurones" @default.
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• W2095114372 doi "https://doi.org/10.1097/00001756-199705060-00002" @default.
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