Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095114564> ?p ?o ?g. }
- W2095114564 endingPage "134" @default.
- W2095114564 startingPage "121" @default.
- W2095114564 abstract "Nanomedicine is the application of nanotechnology to medicine. The purpose of this article is to review common characteristics of polymeric nanomedicines with respect to passive targeting. We consider several biodegradable polymeric nanomedicines that are between 1 and 100 nm in size, and discuss the impact of this technology on efficacy, pharmacokinetics, toxicity and targeting. The degree of toxicity of polymeric nanomedicines is strongly influenced by the biological conditions of the local environment, which influence the rate of degradation or release of polymeric nanomedicines. The dissemination of polymeric nanomedicines in vivo depends on the capillary network, which can provide differential access to normal and tumor cells. The accumulation of nanomedicines in the microlymphatics depends upon retention time in the blood and extracellular compartments, as well as the type of capillary endothelium surrounding specific tissues. Finally, the toxicity or efficacy of intact nanomedicines is also dependent upon tissue type, i.e., non-endocrine or endocrine tissue, spleen, or lymphatics, as well as tumor type." @default.
- W2095114564 created "2016-06-24" @default.
- W2095114564 creator A5058052421 @default.
- W2095114564 date "2008-05-01" @default.
- W2095114564 modified "2023-09-30" @default.
- W2095114564 title "Factors affecting toxicity and efficacy of polymeric nanomedicines" @default.
- W2095114564 cites W1482728771 @default.
- W2095114564 cites W1486348479 @default.
- W2095114564 cites W1573363574 @default.
- W2095114564 cites W1974323623 @default.
- W2095114564 cites W1974920077 @default.
- W2095114564 cites W1985858988 @default.
- W2095114564 cites W1986269836 @default.
- W2095114564 cites W1989440752 @default.
- W2095114564 cites W1990859382 @default.
- W2095114564 cites W1992972854 @default.
- W2095114564 cites W1993866602 @default.
- W2095114564 cites W1999729475 @default.
- W2095114564 cites W2001218108 @default.
- W2095114564 cites W2003888788 @default.
- W2095114564 cites W2008239092 @default.
- W2095114564 cites W2016156919 @default.
- W2095114564 cites W2016285976 @default.
- W2095114564 cites W2020708627 @default.
- W2095114564 cites W2023868317 @default.
- W2095114564 cites W2025036947 @default.
- W2095114564 cites W2035745723 @default.
- W2095114564 cites W2041452578 @default.
- W2095114564 cites W2045020855 @default.
- W2095114564 cites W2046635748 @default.
- W2095114564 cites W2068809055 @default.
- W2095114564 cites W2069059514 @default.
- W2095114564 cites W2070838947 @default.
- W2095114564 cites W2074469414 @default.
- W2095114564 cites W2081908460 @default.
- W2095114564 cites W2094095836 @default.
- W2095114564 cites W2111115146 @default.
- W2095114564 cites W2112927879 @default.
- W2095114564 cites W2166443941 @default.
- W2095114564 cites W2169187623 @default.
- W2095114564 cites W2205528019 @default.
- W2095114564 cites W2315859770 @default.
- W2095114564 cites W2320903235 @default.
- W2095114564 cites W2322363448 @default.
- W2095114564 cites W2322586184 @default.
- W2095114564 cites W326271711 @default.
- W2095114564 doi "https://doi.org/10.1016/j.taap.2008.02.007" @default.
- W2095114564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18355886" @default.
- W2095114564 hasPublicationYear "2008" @default.
- W2095114564 type Work @default.
- W2095114564 sameAs 2095114564 @default.
- W2095114564 citedByCount "74" @default.
- W2095114564 countsByYear W20951145642012 @default.
- W2095114564 countsByYear W20951145642013 @default.
- W2095114564 countsByYear W20951145642014 @default.
- W2095114564 countsByYear W20951145642015 @default.
- W2095114564 countsByYear W20951145642016 @default.
- W2095114564 countsByYear W20951145642017 @default.
- W2095114564 countsByYear W20951145642018 @default.
- W2095114564 countsByYear W20951145642019 @default.
- W2095114564 countsByYear W20951145642020 @default.
- W2095114564 countsByYear W20951145642021 @default.
- W2095114564 countsByYear W20951145642022 @default.
- W2095114564 crossrefType "journal-article" @default.
- W2095114564 hasAuthorship W2095114564A5058052421 @default.
- W2095114564 hasConcept C15083742 @default.
- W2095114564 hasConcept C150903083 @default.
- W2095114564 hasConcept C155672457 @default.
- W2095114564 hasConcept C171250308 @default.
- W2095114564 hasConcept C178790620 @default.
- W2095114564 hasConcept C185592680 @default.
- W2095114564 hasConcept C192562407 @default.
- W2095114564 hasConcept C207001950 @default.
- W2095114564 hasConcept C29730261 @default.
- W2095114564 hasConcept C71924100 @default.
- W2095114564 hasConcept C86803240 @default.
- W2095114564 hasConcept C98274493 @default.
- W2095114564 hasConceptScore W2095114564C15083742 @default.
- W2095114564 hasConceptScore W2095114564C150903083 @default.
- W2095114564 hasConceptScore W2095114564C155672457 @default.
- W2095114564 hasConceptScore W2095114564C171250308 @default.
- W2095114564 hasConceptScore W2095114564C178790620 @default.
- W2095114564 hasConceptScore W2095114564C185592680 @default.
- W2095114564 hasConceptScore W2095114564C192562407 @default.
- W2095114564 hasConceptScore W2095114564C207001950 @default.
- W2095114564 hasConceptScore W2095114564C29730261 @default.
- W2095114564 hasConceptScore W2095114564C71924100 @default.
- W2095114564 hasConceptScore W2095114564C86803240 @default.
- W2095114564 hasConceptScore W2095114564C98274493 @default.
- W2095114564 hasIssue "1" @default.
- W2095114564 hasLocation W20951145641 @default.
- W2095114564 hasLocation W20951145642 @default.
- W2095114564 hasOpenAccess W2095114564 @default.
- W2095114564 hasPrimaryLocation W20951145641 @default.
- W2095114564 hasRelatedWork W1966103943 @default.
- W2095114564 hasRelatedWork W1973645168 @default.
- W2095114564 hasRelatedWork W1987894529 @default.
- W2095114564 hasRelatedWork W2067694292 @default.