Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095122911> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2095122911 endingPage "444" @default.
- W2095122911 startingPage "440" @default.
- W2095122911 abstract "beta-1,4-Galactosyltransferase (GalTase) is present on the surface of mouse sperm, where it functions during fertilization by binding to oligosaccharide residues in the egg zona pellucida. The specific oligosaccharide substrates for sperm GalTase reside on the glycoprotein ZP3, which possesses both sperm-binding and acrosome reaction-inducing activity. A variety of reagents that perturb sperm GalTase activity inhibit sperm binding to the zona pellucida, including UDP-galactose, N-acetylglucosamine, alpha-lactalbumin, and anti-GalTase Fab fragments. However, none of these reagents are able to cross-link GalTase within the membrane nor are they able to induce the acrosome reaction. On the other hand, intact anti-GalTase IgG blocks sperm-zona binding as well as induces the acrosome reaction. Anti-GalTase IgG induces the acrosome reaction by aggregating GalTase on the sperm plasma membrane, as shown by the inability of anti-Gal-Tase Fab fragments to induce the acrosome reaction unless cross-linked with goat anti-rabbit IgG. These data suggest that zona pellucida oligosaccharides induce the acrosome reaction by clustering GalTase on the sperm surface." @default.
- W2095122911 created "2016-06-24" @default.
- W2095122911 creator A5029959891 @default.
- W2095122911 creator A5045315525 @default.
- W2095122911 creator A5084039944 @default.
- W2095122911 date "1991-10-01" @default.
- W2095122911 modified "2023-10-15" @default.
- W2095122911 title "Aggregation of β-1,4-galactosyltransferase on mouse sperm induces the acrosome reaction" @default.
- W2095122911 cites W1521239469 @default.
- W2095122911 cites W1524561975 @default.
- W2095122911 cites W1574150827 @default.
- W2095122911 cites W1825192991 @default.
- W2095122911 cites W1967207742 @default.
- W2095122911 cites W1970022445 @default.
- W2095122911 cites W1992221491 @default.
- W2095122911 cites W2001392134 @default.
- W2095122911 cites W2001892434 @default.
- W2095122911 cites W2025356775 @default.
- W2095122911 cites W2035320944 @default.
- W2095122911 cites W2067978325 @default.
- W2095122911 cites W2071348291 @default.
- W2095122911 cites W2072169540 @default.
- W2095122911 cites W2079734276 @default.
- W2095122911 cites W2085674561 @default.
- W2095122911 cites W2087997490 @default.
- W2095122911 cites W2132738681 @default.
- W2095122911 cites W2143166202 @default.
- W2095122911 cites W2153338537 @default.
- W2095122911 cites W2160118039 @default.
- W2095122911 cites W2163298310 @default.
- W2095122911 cites W2166518804 @default.
- W2095122911 cites W2171752921 @default.
- W2095122911 cites W2298670773 @default.
- W2095122911 doi "https://doi.org/10.1016/0012-1606(91)90301-i" @default.
- W2095122911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1916017" @default.
- W2095122911 hasPublicationYear "1991" @default.
- W2095122911 type Work @default.
- W2095122911 sameAs 2095122911 @default.
- W2095122911 citedByCount "99" @default.
- W2095122911 countsByYear W20951229112016 @default.
- W2095122911 countsByYear W20951229112020 @default.
- W2095122911 crossrefType "journal-article" @default.
- W2095122911 hasAuthorship W2095122911A5029959891 @default.
- W2095122911 hasAuthorship W2095122911A5045315525 @default.
- W2095122911 hasAuthorship W2095122911A5084039944 @default.
- W2095122911 hasConcept C181199279 @default.
- W2095122911 hasConcept C196843134 @default.
- W2095122911 hasConcept C203014093 @default.
- W2095122911 hasConcept C2776010925 @default.
- W2095122911 hasConcept C2776690073 @default.
- W2095122911 hasConcept C2778252442 @default.
- W2095122911 hasConcept C2779995066 @default.
- W2095122911 hasConcept C2780895608 @default.
- W2095122911 hasConcept C2781087480 @default.
- W2095122911 hasConcept C54355233 @default.
- W2095122911 hasConcept C55493867 @default.
- W2095122911 hasConcept C86803240 @default.
- W2095122911 hasConcept C88972607 @default.
- W2095122911 hasConcept C95444343 @default.
- W2095122911 hasConceptScore W2095122911C181199279 @default.
- W2095122911 hasConceptScore W2095122911C196843134 @default.
- W2095122911 hasConceptScore W2095122911C203014093 @default.
- W2095122911 hasConceptScore W2095122911C2776010925 @default.
- W2095122911 hasConceptScore W2095122911C2776690073 @default.
- W2095122911 hasConceptScore W2095122911C2778252442 @default.
- W2095122911 hasConceptScore W2095122911C2779995066 @default.
- W2095122911 hasConceptScore W2095122911C2780895608 @default.
- W2095122911 hasConceptScore W2095122911C2781087480 @default.
- W2095122911 hasConceptScore W2095122911C54355233 @default.
- W2095122911 hasConceptScore W2095122911C55493867 @default.
- W2095122911 hasConceptScore W2095122911C86803240 @default.
- W2095122911 hasConceptScore W2095122911C88972607 @default.
- W2095122911 hasConceptScore W2095122911C95444343 @default.
- W2095122911 hasIssue "2" @default.
- W2095122911 hasLocation W20951229111 @default.
- W2095122911 hasLocation W20951229112 @default.
- W2095122911 hasOpenAccess W2095122911 @default.
- W2095122911 hasPrimaryLocation W20951229111 @default.
- W2095122911 hasRelatedWork W2010097848 @default.
- W2095122911 hasRelatedWork W2056224886 @default.
- W2095122911 hasRelatedWork W2073741168 @default.
- W2095122911 hasRelatedWork W2103609214 @default.
- W2095122911 hasRelatedWork W2142389296 @default.
- W2095122911 hasRelatedWork W2152288747 @default.
- W2095122911 hasRelatedWork W2368085596 @default.
- W2095122911 hasRelatedWork W2912404326 @default.
- W2095122911 hasRelatedWork W2332994295 @default.
- W2095122911 hasRelatedWork W2982573237 @default.
- W2095122911 hasVolume "147" @default.
- W2095122911 isParatext "false" @default.
- W2095122911 isRetracted "false" @default.
- W2095122911 magId "2095122911" @default.
- W2095122911 workType "article" @default.