FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095129871> ?p ?o ?g. }

• W2095129871 endingPage "137" @default.
• W2095129871 startingPage "129" @default.
• W2095129871 abstract "Studies were undertaken to compare outcomes when four chemicals were evaluated under typical NTP bioassay conditions as well as by protocols employing dietary restriction. Four Chemicals, using three different routes of exposure (in utero [accomplished by feeding the dam dosed feed], dosed feed, and gavage) were used to 1) evaluate the effect of diet restriction on the sensitivity of the bioassay toward chemically-induced chronic toxicity and carcinogenicity; and 2) evaluate the effect of weight-matched control groups on the sensitivity of the bioassays. Control and chemical exposed F344 rats and B6C3F1 mice (50–60/group) were fed NIH-07 diet either ad libitum or at restricted levels such that body weights were ~80 % of ad libitum control weights. The dietary restricted groups were either sacrificed at the end of two or 3-years. Results consistently show that feed restriction decreased the incidence of neoplastic and non-neoplastic lesions at a variety of anatomic sites in both control and chemical exposed animals. Furthermore, the sensitivity of the bioassay to detect chemical carcinogenic response were altered by dietary restriction: three of the four chemicals were found to increase the incidence of neoplastic lesions at four sites when evaluated under standard ad libitum conditions for 104 weeks. When unexposed and exposed groups were both subjected to dietary restriction, none of these 4 sites were detected as a target for carcinogenesis after two or three years. Rather, two different sites of carcinogenesis were detected. When the top dosed ad libitum fed animals were compared against their weight-matched control groups, a total of 10 sites were identified as targets for carcinogenesis. These included all four sites identified under the ad libitum protocol, both sites identified unter the feed restricted protocol, and an additional four sites that were not identified under the other two protocols. These studies show that dietary restriction of all animals can be expected of decrease the sensitivity of carcinogenesis bioassays. However, restricting only unexposed groups (weight matching) of control for non-specific weight loss in chemical exposed groups yielded the most sensitivity among our comparisons." @default.
• W2095129871 created "2016-06-24" @default.
• W2095129871 creator A5000683146 @default.
• W2095129871 creator A5079741334 @default.
• W2095129871 date "1996-02-01" @default.
• W2095129871 modified "2023-10-10" @default.
• W2095129871 title "The sensitivity of the NTP bioassay for carcinogen hazard evaluation can be modulated by dietary restriction" @default.
• W2095129871 cites W1960724357 @default.
• W2095129871 cites W1965217275 @default.
• W2095129871 cites W1972361162 @default.
• W2095129871 cites W2011580519 @default.
• W2095129871 cites W2015807534 @default.
• W2095129871 cites W2031823980 @default.
• W2095129871 cites W2049484908 @default.
• W2095129871 cites W2053524114 @default.
• W2095129871 cites W2070083253 @default.
• W2095129871 cites W2079033298 @default.
• W2095129871 cites W2086222182 @default.
• W2095129871 cites W2087889816 @default.
• W2095129871 cites W2104865387 @default.
• W2095129871 cites W2128647284 @default.
• W2095129871 cites W2158567619 @default.
• W2095129871 cites W2163715537 @default.
• W2095129871 doi "https://doi.org/10.1016/s0940-2993(96)80033-9" @default.
• W2095129871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8672866" @default.
• W2095129871 hasPublicationYear "1996" @default.
• W2095129871 type Work @default.
• W2095129871 sameAs 2095129871 @default.
• W2095129871 citedByCount "28" @default.
• W2095129871 countsByYear W20951298712013 @default.
• W2095129871 countsByYear W20951298712014 @default.
• W2095129871 countsByYear W20951298712017 @default.
• W2095129871 countsByYear W20951298712021 @default.
• W2095129871 countsByYear W20951298712022 @default.
• W2095129871 crossrefType "journal-article" @default.
• W2095129871 hasAuthorship W2095129871A5000683146 @default.
• W2095129871 hasAuthorship W2095129871A5079741334 @default.
• W2095129871 hasConcept C104488531 @default.
• W2095129871 hasConcept C114246631 @default.
• W2095129871 hasConcept C121608353 @default.
• W2095129871 hasConcept C126322002 @default.
• W2095129871 hasConcept C134018914 @default.
• W2095129871 hasConcept C140793950 @default.
• W2095129871 hasConcept C147583825 @default.
• W2095129871 hasConcept C29730261 @default.
• W2095129871 hasConcept C33070731 @default.
• W2095129871 hasConcept C42407357 @default.
• W2095129871 hasConcept C54355233 @default.
• W2095129871 hasConcept C55493867 @default.
• W2095129871 hasConcept C555283112 @default.
• W2095129871 hasConcept C71924100 @default.
• W2095129871 hasConcept C86803240 @default.
• W2095129871 hasConceptScore W2095129871C104488531 @default.
• W2095129871 hasConceptScore W2095129871C114246631 @default.
• W2095129871 hasConceptScore W2095129871C121608353 @default.
• W2095129871 hasConceptScore W2095129871C126322002 @default.
• W2095129871 hasConceptScore W2095129871C134018914 @default.
• W2095129871 hasConceptScore W2095129871C140793950 @default.
• W2095129871 hasConceptScore W2095129871C147583825 @default.
• W2095129871 hasConceptScore W2095129871C29730261 @default.
• W2095129871 hasConceptScore W2095129871C33070731 @default.
• W2095129871 hasConceptScore W2095129871C42407357 @default.
• W2095129871 hasConceptScore W2095129871C54355233 @default.
• W2095129871 hasConceptScore W2095129871C55493867 @default.
• W2095129871 hasConceptScore W2095129871C555283112 @default.
• W2095129871 hasConceptScore W2095129871C71924100 @default.
• W2095129871 hasConceptScore W2095129871C86803240 @default.
• W2095129871 hasIssue "2-3" @default.
• W2095129871 hasLocation W20951298711 @default.
• W2095129871 hasLocation W20951298712 @default.
• W2095129871 hasOpenAccess W2095129871 @default.
• W2095129871 hasPrimaryLocation W20951298711 @default.
• W2095129871 hasRelatedWork W1709688772 @default.
• W2095129871 hasRelatedWork W2040231334 @default.
• W2095129871 hasRelatedWork W2061752523 @default.
• W2095129871 hasRelatedWork W2073076114 @default.
• W2095129871 hasRelatedWork W2101110732 @default.
• W2095129871 hasRelatedWork W2117132430 @default.
• W2095129871 hasRelatedWork W2186887461 @default.
• W2095129871 hasRelatedWork W2368899332 @default.
• W2095129871 hasRelatedWork W2416560908 @default.
• W2095129871 hasRelatedWork W2188407313 @default.
• W2095129871 hasVolume "48" @default.
• W2095129871 isParatext "false" @default.
• W2095129871 isRetracted "false" @default.
• W2095129871 magId "2095129871" @default.
• W2095129871 workType "article" @default.