Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095132175> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2095132175 endingPage "174" @default.
- W2095132175 startingPage "167" @default.
- W2095132175 abstract "We have investigated the effects of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK801), a non-competitive N-methyl-d-aspartate (NMDA) ionotropic excitatory amino acid receptor antagonist, and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a non-NMDA ionotropic excitatory amino acid receptor antagonist, ketamine and memantine, NMDA receptor channel blockers, on ventricular arrhythmias induced by myocardial ischaemia and myocardial ischaemia-reperfusion. Coronary artery occlusion caused 100±2% ventricular tachycardia, in saline treated group, and 60±3% ventricular fibrillation. 66±6% of the animals recovered from ventricular fibrillation, while in 34±4% of animals the ventricular fibrillation caused mortality. The incidence of ventricular tachycardia, ventricular fibrillation and mortality was not modified by treatment of rats with MK801 (0.3 mg/kg i.v.), CNQX (1 mg/kg i.v.), ketamine (10 mg/kg) and memantine (1.5 mg/kg), injected 5 min prior to occlusion. Reperfusion caused severe arrhythmias which started within 5±2 s. For instance, in the saline treated group, the incidence of ventricular tachycardia was 100±5%, while ventricular fibrillation occurred in 87±3% of the animals and lasted 90±12 s. The mortality was 62±6%. The incidence of ventricular tachycardia, ventricular fibrillation and mortality induced by reperfusion was greatly (P<0.01) reduced in animals treated with MK801 (0.3 mg/kg i.v.), CNQX (1 mg/kg i.v.), ketamine (10 mg/kg) and memantine (1.5 mg/kg), injected 5 min prior to occlusion. Therefore, reperfusion-induced arrhythmias, but not ischaemia-induced arrhythmias, are sensitive to NMDA/non-NMDA ionotropic excitatory amino acid receptor antagonists." @default.
- W2095132175 created "2016-06-24" @default.
- W2095132175 creator A5014850119 @default.
- W2095132175 creator A5019917464 @default.
- W2095132175 creator A5039611978 @default.
- W2095132175 creator A5085334357 @default.
- W2095132175 date "1999-02-01" @default.
- W2095132175 modified "2023-09-23" @default.
- W2095132175 title "Arrhythmias induced by myocardial ischaemia-reperfusion are sensitive to ionotropic excitatory amino acid receptor antagonists" @default.
- W2095132175 cites W1968840823 @default.
- W2095132175 cites W1978997100 @default.
- W2095132175 cites W1983352870 @default.
- W2095132175 cites W2019393175 @default.
- W2095132175 cites W2020516051 @default.
- W2095132175 cites W2052698671 @default.
- W2095132175 cites W2058779467 @default.
- W2095132175 cites W2073153488 @default.
- W2095132175 cites W2078683922 @default.
- W2095132175 cites W2122930160 @default.
- W2095132175 cites W2148342016 @default.
- W2095132175 cites W2170029299 @default.
- W2095132175 cites W250135094 @default.
- W2095132175 doi "https://doi.org/10.1016/s0014-2999(98)00914-5" @default.
- W2095132175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10082197" @default.
- W2095132175 hasPublicationYear "1999" @default.
- W2095132175 type Work @default.
- W2095132175 sameAs 2095132175 @default.
- W2095132175 citedByCount "36" @default.
- W2095132175 countsByYear W20951321752012 @default.
- W2095132175 countsByYear W20951321752014 @default.
- W2095132175 countsByYear W20951321752015 @default.
- W2095132175 countsByYear W20951321752016 @default.
- W2095132175 countsByYear W20951321752017 @default.
- W2095132175 countsByYear W20951321752018 @default.
- W2095132175 countsByYear W20951321752019 @default.
- W2095132175 countsByYear W20951321752020 @default.
- W2095132175 countsByYear W20951321752021 @default.
- W2095132175 countsByYear W20951321752022 @default.
- W2095132175 countsByYear W20951321752023 @default.
- W2095132175 crossrefType "journal-article" @default.
- W2095132175 hasAuthorship W2095132175A5014850119 @default.
- W2095132175 hasAuthorship W2095132175A5019917464 @default.
- W2095132175 hasAuthorship W2095132175A5039611978 @default.
- W2095132175 hasAuthorship W2095132175A5085334357 @default.
- W2095132175 hasConcept C126322002 @default.
- W2095132175 hasConcept C160268369 @default.
- W2095132175 hasConcept C164705383 @default.
- W2095132175 hasConcept C170493617 @default.
- W2095132175 hasConcept C2776331378 @default.
- W2095132175 hasConcept C2779803574 @default.
- W2095132175 hasConcept C2780393670 @default.
- W2095132175 hasConcept C2781005686 @default.
- W2095132175 hasConcept C42219234 @default.
- W2095132175 hasConcept C541997718 @default.
- W2095132175 hasConcept C67018056 @default.
- W2095132175 hasConcept C71924100 @default.
- W2095132175 hasConceptScore W2095132175C126322002 @default.
- W2095132175 hasConceptScore W2095132175C160268369 @default.
- W2095132175 hasConceptScore W2095132175C164705383 @default.
- W2095132175 hasConceptScore W2095132175C170493617 @default.
- W2095132175 hasConceptScore W2095132175C2776331378 @default.
- W2095132175 hasConceptScore W2095132175C2779803574 @default.
- W2095132175 hasConceptScore W2095132175C2780393670 @default.
- W2095132175 hasConceptScore W2095132175C2781005686 @default.
- W2095132175 hasConceptScore W2095132175C42219234 @default.
- W2095132175 hasConceptScore W2095132175C541997718 @default.
- W2095132175 hasConceptScore W2095132175C67018056 @default.
- W2095132175 hasConceptScore W2095132175C71924100 @default.
- W2095132175 hasIssue "2-3" @default.
- W2095132175 hasLocation W20951321751 @default.
- W2095132175 hasLocation W20951321752 @default.
- W2095132175 hasOpenAccess W2095132175 @default.
- W2095132175 hasPrimaryLocation W20951321751 @default.
- W2095132175 hasRelatedWork W1534090624 @default.
- W2095132175 hasRelatedWork W1977144318 @default.
- W2095132175 hasRelatedWork W1991344869 @default.
- W2095132175 hasRelatedWork W2027787775 @default.
- W2095132175 hasRelatedWork W2030004221 @default.
- W2095132175 hasRelatedWork W2030597331 @default.
- W2095132175 hasRelatedWork W2051460071 @default.
- W2095132175 hasRelatedWork W2069600595 @default.
- W2095132175 hasRelatedWork W2414946388 @default.
- W2095132175 hasRelatedWork W3141230760 @default.
- W2095132175 hasVolume "366" @default.
- W2095132175 isParatext "false" @default.
- W2095132175 isRetracted "false" @default.
- W2095132175 magId "2095132175" @default.
- W2095132175 workType "article" @default.