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• W2095133085 abstract "To investigate risk factors for hepatocellular carcinoma (HCC) in Italy—a country with medium (south: 5% to 10%) to low (north: 1% to 2%) incidence of hepatitis B virus (HBV) infection—we studied 646 consecutive patients: 58 chronic active hepatitis (CAH), 428 cirrhosis, and 160 HCC, 49% from Southern and 51% from Northern Italy. Hepatitis B surface antigen (HBsAg) was positive in 41.4% of the CAH, in 23.1% of cirrhotic patients, and in 26.2% of HCC. In the latter, HBV DNA assay increased the number of subjects with active HBV infection by about 12%. Alcohol abuse was evenly distributed in all three categories of HBV markers. Males were preferentially affected. The HCC was superimposed on cirrhosis in more than 90% of patients. Our data suggest that, in our epidemiologic setting, different factors (HBV, non-A, non-B agents, alcohol) may cooperate in the development of HCC, mainly through their potential for causing cirrhosis." @default.
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• W2095133085 date "1988-08-01" @default.
• W2095133085 modified "2023-09-22" @default.
• W2095133085 title "Risk factors for hepatocellular carcinoma in italy. Male sex, hepatitis b virus, non-a non-B infection, and alcohol" @default.
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• W2095133085 doi "https://doi.org/10.1002/1097-0142(19880801)62:3<611::aid-cncr2820620328>3.0.co;2-0" @default.
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