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• W2095138601 abstract "RATIONALE: Fractional exhaled nitric oxide (FeNO) is elevated in asthmatic and atopic children. Collection of FeNO at multiple flow rates is used to calculate flow-independent parameters of airway NO exchange which could help distinguish between atopy and wheeze related elevated FeNO.METHODS: As part of a birth cohort study (CCCEH), nine-year old children (n = 50) of African-American and Dominican mothers living in low-income NYC neighborhoods were tested utilizing the offline NO collection method. FeNO samples were obtained at constant flows of 50, 83 and 100 mL/sec. The lowest and highest flows were collected in duplicate and the medium flow in triplicate. Current wheeze was assessed by ISAAC questionnaire. For 39 children total IgE was assessed at age 7 years. Flow rate and mean FeNO values were plotted versus total NO output to determine the flow-independent parameters, bronchial flux (JNO) and alveolar concentration (Calv). Data were analyzed using non-parametric tests.RESULTS: Children with wheeze in the last year (16%) had significantly higher FeNO at all flow rates (e.g. at 83 mL/s: 19.7 vs 10.3ppb, p = 0.021) and Calv (10.1 vs 5.4ppb, p = 0.002) when compared with children without wheeze. Log transformed total IgE concentrations were positively correlated with FeNO at all flow rates (83 mL/s: p = 0.008) and JNO (p = 0.001). However, there was no correlation between Calv and total IgE (p = 0.947).CONCLUSIONS: The multiple flow method allows partitioning of NO contributions from peripheral and distal airways. Flow independent parameters could help distinguish elevated FeNO levels related to asthma symptoms from those due to atopy in the absence of asthma symptoms. RATIONALE: Fractional exhaled nitric oxide (FeNO) is elevated in asthmatic and atopic children. Collection of FeNO at multiple flow rates is used to calculate flow-independent parameters of airway NO exchange which could help distinguish between atopy and wheeze related elevated FeNO. METHODS: As part of a birth cohort study (CCCEH), nine-year old children (n = 50) of African-American and Dominican mothers living in low-income NYC neighborhoods were tested utilizing the offline NO collection method. FeNO samples were obtained at constant flows of 50, 83 and 100 mL/sec. The lowest and highest flows were collected in duplicate and the medium flow in triplicate. Current wheeze was assessed by ISAAC questionnaire. For 39 children total IgE was assessed at age 7 years. Flow rate and mean FeNO values were plotted versus total NO output to determine the flow-independent parameters, bronchial flux (JNO) and alveolar concentration (Calv). Data were analyzed using non-parametric tests. RESULTS: Children with wheeze in the last year (16%) had significantly higher FeNO at all flow rates (e.g. at 83 mL/s: 19.7 vs 10.3ppb, p = 0.021) and Calv (10.1 vs 5.4ppb, p = 0.002) when compared with children without wheeze. Log transformed total IgE concentrations were positively correlated with FeNO at all flow rates (83 mL/s: p = 0.008) and JNO (p = 0.001). However, there was no correlation between Calv and total IgE (p = 0.947). CONCLUSIONS: The multiple flow method allows partitioning of NO contributions from peripheral and distal airways. Flow independent parameters could help distinguish elevated FeNO levels related to asthma symptoms from those due to atopy in the absence of asthma symptoms." @default.
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• W2095138601 date "2009-02-01" @default.
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• W2095138601 title "Flow-Dependent and Independent Parameters of Exhaled Nitric Oxide in 9 Year-Old Children Living in Low-Income NYC Communities" @default.
• W2095138601 doi "https://doi.org/10.1016/j.jaci.2008.12.029" @default.
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