FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095145940> ?p ?o ?g. }

• W2095145940 endingPage "364" @default.
• W2095145940 startingPage "357" @default.
• W2095145940 abstract "Given the role of xenoreactive natural antibodies (XNA) in the pathogenesis of xenograft rejection, we tested whether the administration of anti-mu or anti-delta monoclonal antibodies (mAbs) in adult rats would suppress the generation of XNA.Adult LOU/C (Igkappa-1a) rats were treated with anti-mu or anti-delta mAbs after nonlethal total body irradiation and bone marrow transplantation from congenic LOU/C (Igkappa-1b) rats. The differentiation of donor bone marrow (BM)-driven Igkappa-1b+ B cells and XNA production were analyzed.Both anti-mu and anti-delta mAbs arrested B-cell differentiation in the BM. In anti-mu-treated rats, there was a total depletion of donor-driven, peripheral Igkappa-1b+ B cells, secreting cells, and circulating XNA of the Igkappa-1b allotype. In anti-delta-treated rats, a significant number of Igkappa-1b+ B cells, which did not express membrane IgD, escaped deletion and partially repopulated peripheral lymphoid organs. This B-cell population was active in the production of XNA, as revealed by the high serum levels of XNA in these animals.Anti-mu administration resulted in arrest of B-cell differentiation and in down-regulation of IgM and IgG XNA production in adult rats. These data suggest that the use of anti-mu mAbs may be a useful approach to suppress the production of XNA and prevent xenograft rejection. Furthermore, we suggest that the B-cell population responsible for the production of XNA in adult rats belongs to a B-cell lineage expressing low levels of membrane IgD and escaping deletion in the BM upon anti-delta treatment." @default.
• W2095145940 created "2016-06-24" @default.
• W2095145940 creator A5010907671 @default.
• W2095145940 creator A5016033018 @default.
• W2095145940 creator A5025779543 @default.
• W2095145940 creator A5044803861 @default.
• W2095145940 creator A5057867500 @default.
• W2095145940 creator A5067643807 @default.
• W2095145940 creator A5071978578 @default.
• W2095145940 creator A5074437563 @default.
• W2095145940 creator A5083864242 @default.
• W2095145940 date "1998-08-01" @default.
• W2095145940 modified "2023-09-27" @default.
• W2095145940 title "DIFFERENTIAL INHIBITION OF B-CELL DEVELOPMENT AND XENOREACTIVE NATURAL ANTIBODY PRODUCTION BY ADMINISTRATION OF ANTI-?? OR ANTI-?? MONOCLONAL ANTIBODIES IN ADULT RATS1" @default.
• W2095145940 cites W1577538717 @default.
• W2095145940 cites W1966949480 @default.
• W2095145940 cites W1981863728 @default.
• W2095145940 cites W1983111776 @default.
• W2095145940 cites W1988417835 @default.
• W2095145940 cites W2000061036 @default.
• W2095145940 cites W2004054985 @default.
• W2095145940 cites W2005869248 @default.
• W2095145940 cites W2016208323 @default.
• W2095145940 cites W2020427241 @default.
• W2095145940 cites W2020909382 @default.
• W2095145940 cites W2032660841 @default.
• W2095145940 cites W2043731244 @default.
• W2095145940 cites W2047824823 @default.
• W2095145940 cites W2049234532 @default.
• W2095145940 cites W2052438035 @default.
• W2095145940 cites W2052816795 @default.
• W2095145940 cites W2074268860 @default.
• W2095145940 cites W2078702573 @default.
• W2095145940 cites W2083502535 @default.
• W2095145940 cites W2105520444 @default.
• W2095145940 cites W2131074235 @default.
• W2095145940 cites W2134424755 @default.
• W2095145940 cites W2145524613 @default.
• W2095145940 cites W2148591507 @default.
• W2095145940 cites W2157839473 @default.
• W2095145940 cites W2163431518 @default.
• W2095145940 cites W2172123653 @default.
• W2095145940 cites W4231035875 @default.
• W2095145940 doi "https://doi.org/10.1097/00007890-199808150-00013" @default.
• W2095145940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9721805" @default.
• W2095145940 hasPublicationYear "1998" @default.
• W2095145940 type Work @default.
• W2095145940 sameAs 2095145940 @default.
• W2095145940 citedByCount "6" @default.
• W2095145940 crossrefType "journal-article" @default.
• W2095145940 hasAuthorship W2095145940A5010907671 @default.
• W2095145940 hasAuthorship W2095145940A5016033018 @default.
• W2095145940 hasAuthorship W2095145940A5025779543 @default.
• W2095145940 hasAuthorship W2095145940A5044803861 @default.
• W2095145940 hasAuthorship W2095145940A5057867500 @default.
• W2095145940 hasAuthorship W2095145940A5067643807 @default.
• W2095145940 hasAuthorship W2095145940A5071978578 @default.
• W2095145940 hasAuthorship W2095145940A5074437563 @default.
• W2095145940 hasAuthorship W2095145940A5083864242 @default.
• W2095145940 hasBestOaLocation W20951459401 @default.
• W2095145940 hasConcept C126322002 @default.
• W2095145940 hasConcept C153911025 @default.
• W2095145940 hasConcept C159654299 @default.
• W2095145940 hasConcept C195616568 @default.
• W2095145940 hasConcept C203014093 @default.
• W2095145940 hasConcept C2778453870 @default.
• W2095145940 hasConcept C2780007613 @default.
• W2095145940 hasConcept C2908647359 @default.
• W2095145940 hasConcept C2911091166 @default.
• W2095145940 hasConcept C48010095 @default.
• W2095145940 hasConcept C542903549 @default.
• W2095145940 hasConcept C71924100 @default.
• W2095145940 hasConcept C86803240 @default.
• W2095145940 hasConcept C99454951 @default.
• W2095145940 hasConceptScore W2095145940C126322002 @default.
• W2095145940 hasConceptScore W2095145940C153911025 @default.
• W2095145940 hasConceptScore W2095145940C159654299 @default.
• W2095145940 hasConceptScore W2095145940C195616568 @default.
• W2095145940 hasConceptScore W2095145940C203014093 @default.
• W2095145940 hasConceptScore W2095145940C2778453870 @default.
• W2095145940 hasConceptScore W2095145940C2780007613 @default.
• W2095145940 hasConceptScore W2095145940C2908647359 @default.
• W2095145940 hasConceptScore W2095145940C2911091166 @default.
• W2095145940 hasConceptScore W2095145940C48010095 @default.
• W2095145940 hasConceptScore W2095145940C542903549 @default.
• W2095145940 hasConceptScore W2095145940C71924100 @default.
• W2095145940 hasConceptScore W2095145940C86803240 @default.
• W2095145940 hasConceptScore W2095145940C99454951 @default.
• W2095145940 hasIssue "3" @default.
• W2095145940 hasLocation W20951459401 @default.
• W2095145940 hasLocation W20951459402 @default.
• W2095145940 hasLocation W20951459403 @default.
• W2095145940 hasOpenAccess W2095145940 @default.
• W2095145940 hasPrimaryLocation W20951459401 @default.
• W2095145940 hasRelatedWork W1515404900 @default.
• W2095145940 hasRelatedWork W195682249 @default.
• W2095145940 hasRelatedWork W1981898410 @default.
• W2095145940 hasRelatedWork W2059923545 @default.

• next