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- W2095147188 abstract "alpha factor is a negative growth factor and differentiation factor that induces G1 arrest and increases transcription of mating genes in S. cerevisiae a cells. We have identified a gene, FAR1 (for factor arrest), which is necessary for cell cycle arrest but not for other responses to alpha factor: far1- mutants are insensitive to arrest despite having an intact signal transduction pathway. FAR1 is a nonessential gene whose expression is induced 4- to 5-fold in a cells by alpha factor. The sequence of FAR1 indicates no significant similarities to known proteins. A null mutation in the CLN2 gene, which codes for a G1 cyclin, reverses the effect of a far1 null mutation: far1- cln2- strains arrest in response to alpha factor. We thus propose that FAR1 contributes to cell cycle arrest by inhibiting CLN2. The behavior of far1- cln2- strains indicates that products other than FAR1 are responsible for inhibiting the other G1 cyclins, CLN1 and CLN3." @default.
- W2095147188 created "2016-06-24" @default.
- W2095147188 creator A5066764016 @default.
- W2095147188 creator A5082789932 @default.
- W2095147188 date "1990-11-01" @default.
- W2095147188 modified "2023-10-03" @default.
- W2095147188 title "Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2" @default.
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- W2095147188 doi "https://doi.org/10.1016/0092-8674(90)90503-7" @default.
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