Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095147852> ?p ?o ?g. }
- W2095147852 endingPage "284" @default.
- W2095147852 startingPage "269" @default.
- W2095147852 abstract "Summary. An acquired haemorrhagic syndrome is described in which the failure of haemostasis is due to impaired crosslinking of fibrin. This defect, demonstrated by both monochloroacetic acid clot-solubility test and disc-gel electrophoretic analysis of individual fibrin chains, existed despite normal fibrin stabilizing factor (factor XIII) levels in the patient's plasma. Activation of the factor by thrombin, measured by amine incorporation into casein, was normal. The unique molecular defect in this patient could be fully accounted for by the presence of an inhibitory IgG antibody against the crosslinking sites in fibrinogen-fibrin. No alteration could be seen in either the rate or in the extent of the reversible aggregation of fibrin. However, large amounts of cryoprecipitate were found in the patient's plasma. This phenomenon could be reproduced in vitro by incubating the chromatographically purified IgG of the patient with normal fibrinogen at 4°C. It is conceivable that the antibody in the patient could have arisen in response to the modification of normal fibrinogen by isonicotinic acid hydrazide which the patient had ingested for 8 yr." @default.
- W2095147852 created "2016-06-24" @default.
- W2095147852 creator A5023311552 @default.
- W2095147852 creator A5032544708 @default.
- W2095147852 creator A5069143752 @default.
- W2095147852 date "1974-02-01" @default.
- W2095147852 modified "2023-09-26" @default.
- W2095147852 title "A New Haemorrhagic Disorder with Defective Fibrin Stabilization and Cryofibrinogenaemia" @default.
- W2095147852 cites W1544756659 @default.
- W2095147852 cites W1554490272 @default.
- W2095147852 cites W1584504330 @default.
- W2095147852 cites W1625660792 @default.
- W2095147852 cites W1750773183 @default.
- W2095147852 cites W194737756 @default.
- W2095147852 cites W1964281316 @default.
- W2095147852 cites W1964661630 @default.
- W2095147852 cites W1968770463 @default.
- W2095147852 cites W1975580765 @default.
- W2095147852 cites W1981438065 @default.
- W2095147852 cites W1987446470 @default.
- W2095147852 cites W1990853221 @default.
- W2095147852 cites W2004639360 @default.
- W2095147852 cites W2004709625 @default.
- W2095147852 cites W2011275596 @default.
- W2095147852 cites W2012171708 @default.
- W2095147852 cites W2012214760 @default.
- W2095147852 cites W2026475911 @default.
- W2095147852 cites W2029405287 @default.
- W2095147852 cites W2029516545 @default.
- W2095147852 cites W2032109855 @default.
- W2095147852 cites W2035989734 @default.
- W2095147852 cites W2036956293 @default.
- W2095147852 cites W2040158950 @default.
- W2095147852 cites W2045202161 @default.
- W2095147852 cites W2045205744 @default.
- W2095147852 cites W2046153111 @default.
- W2095147852 cites W2054517366 @default.
- W2095147852 cites W2085213487 @default.
- W2095147852 cites W2088282977 @default.
- W2095147852 cites W2095204534 @default.
- W2095147852 cites W2145863516 @default.
- W2095147852 cites W2157416857 @default.
- W2095147852 cites W2160805842 @default.
- W2095147852 cites W2317789854 @default.
- W2095147852 cites W2333330110 @default.
- W2095147852 cites W2336333758 @default.
- W2095147852 cites W2340602354 @default.
- W2095147852 cites W2341168771 @default.
- W2095147852 cites W4240149712 @default.
- W2095147852 doi "https://doi.org/10.1111/j.1365-2141.1974.tb00472.x" @default.
- W2095147852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4843743" @default.
- W2095147852 hasPublicationYear "1974" @default.
- W2095147852 type Work @default.
- W2095147852 sameAs 2095147852 @default.
- W2095147852 citedByCount "48" @default.
- W2095147852 countsByYear W20951478522012 @default.
- W2095147852 countsByYear W20951478522013 @default.
- W2095147852 countsByYear W20951478522016 @default.
- W2095147852 countsByYear W20951478522017 @default.
- W2095147852 countsByYear W20951478522018 @default.
- W2095147852 countsByYear W20951478522022 @default.
- W2095147852 crossrefType "journal-article" @default.
- W2095147852 hasAuthorship W2095147852A5023311552 @default.
- W2095147852 hasAuthorship W2095147852A5032544708 @default.
- W2095147852 hasAuthorship W2095147852A5069143752 @default.
- W2095147852 hasConcept C155574463 @default.
- W2095147852 hasConcept C159654299 @default.
- W2095147852 hasConcept C178790620 @default.
- W2095147852 hasConcept C185592680 @default.
- W2095147852 hasConcept C203014093 @default.
- W2095147852 hasConcept C2777292125 @default.
- W2095147852 hasConcept C2778258694 @default.
- W2095147852 hasConcept C2779036427 @default.
- W2095147852 hasConcept C2779672106 @default.
- W2095147852 hasConcept C54173615 @default.
- W2095147852 hasConcept C55493867 @default.
- W2095147852 hasConcept C71924100 @default.
- W2095147852 hasConcept C89560881 @default.
- W2095147852 hasConceptScore W2095147852C155574463 @default.
- W2095147852 hasConceptScore W2095147852C159654299 @default.
- W2095147852 hasConceptScore W2095147852C178790620 @default.
- W2095147852 hasConceptScore W2095147852C185592680 @default.
- W2095147852 hasConceptScore W2095147852C203014093 @default.
- W2095147852 hasConceptScore W2095147852C2777292125 @default.
- W2095147852 hasConceptScore W2095147852C2778258694 @default.
- W2095147852 hasConceptScore W2095147852C2779036427 @default.
- W2095147852 hasConceptScore W2095147852C2779672106 @default.
- W2095147852 hasConceptScore W2095147852C54173615 @default.
- W2095147852 hasConceptScore W2095147852C55493867 @default.
- W2095147852 hasConceptScore W2095147852C71924100 @default.
- W2095147852 hasConceptScore W2095147852C89560881 @default.
- W2095147852 hasIssue "2" @default.
- W2095147852 hasLocation W20951478521 @default.
- W2095147852 hasLocation W20951478522 @default.
- W2095147852 hasOpenAccess W2095147852 @default.
- W2095147852 hasPrimaryLocation W20951478521 @default.
- W2095147852 hasRelatedWork W2007707310 @default.
- W2095147852 hasRelatedWork W2012171708 @default.