FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095157185> ?p ?o ?g. }

• W2095157185 endingPage "446" @default.
• W2095157185 startingPage "446" @default.
• W2095157185 abstract "<h3>Importance</h3> Several large-scale Alzheimer disease (AD) secondary prevention trials have begun to target individuals at the preclinical stage. The success of these trials depends on validated outcome measures that are sensitive to early clinical progression in individuals who are initially asymptomatic. <h3>Objective</h3> To investigate the utility of the Cognitive Function Instrument (CFI) to track early changes in cognitive function in older individuals without clinical impairment at baseline. <h3>Design, Setting, and Participants</h3> Longitudinal study from February 2002 through February 2007 at participating Alzheimer’s Disease Cooperative Study sites. Individuals were followed up annually for 48 months after the baseline visit. The study included 468 healthy older individuals (Clinical Dementia Rating scale [CDR] global scores of 0, above cutoff on the modified Mini-Mental State Examination and Free and Cued Selective Reminding Test) (mean [SD] age, 79.4 [3.6] years; age range, 75.0-93.8 years). All study participants and their study partners completed the self and partner CFIs annually. Individuals also underwent concurrent annual neuropsychological assessment and<i>APOE</i>genotyping. <h3>Main Outcomes and Measures</h3> The CFI scores between clinical progressors (CDR score, ≥0.5) and nonprogressors (CDR score, 0) and between<i>APOE </i>ε4 carriers and noncarriers were compared. Correlations of change between the CFI scores and neuropsychological performance were assessed longitudinally. <h3>Results</h3> At 48 months, group differences between clinical progressors and non-progressors were significant for self (2.13, SE=0.45,<i>P</i> < .001), partner (5.08, SE=0.59,<i>P</i> < .001), and self plus partner (7.04, SE=0.83,<i>P</i> < .001) CFI total scores. At month 48,<i>APOE</i>ε4 carriers had greater progression than noncarriers on the partner (1.10, SE=0.44,<i>P</i> < .012) and self plus partner (1.56, SE=0.63,<i>P</i> < .014) CFI scores. Both self and partner CFI change were associated with longitudinal cognitive decline (self, ρ=0.32, 95% CI, 0.13 to 0.46; partner, ρ=0.56, 95% CI, 0.42 to 0.68), although findings suggest self-report may be more accurate early in the process, whereas accuracy of partner report improves when there is progression to cognitive impairment. <h3>Conclusions and Relevance</h3> Demonstrating long-term clinical benefit will be critical for the success of recently launched secondary prevention trials. The CFI appears to be a brief, but informative potential outcome measure that provides insight into functional abilities at the earliest stages of disease." @default.
• W2095157185 created "2016-06-24" @default.
• W2095157185 creator A5001795846 @default.
• W2095157185 creator A5030911639 @default.
• W2095157185 creator A5034225628 @default.
• W2095157185 creator A5056034076 @default.
• W2095157185 creator A5062039064 @default.
• W2095157185 creator A5074253440 @default.
• W2095157185 creator A5076768887 @default.
• W2095157185 creator A5081258864 @default.
• W2095157185 creator A5084568106 @default.
• W2095157185 date "2015-04-01" @default.
• W2095157185 modified "2023-10-02" @default.
• W2095157185 title "Tracking Early Decline in Cognitive Function in Older Individuals at Risk for Alzheimer Disease Dementia" @default.
• W2095157185 cites W1523725480 @default.
• W2095157185 cites W1964464904 @default.
• W2095157185 cites W1971351343 @default.
• W2095157185 cites W1975005502 @default.
• W2095157185 cites W1991952617 @default.
• W2095157185 cites W1995779519 @default.
• W2095157185 cites W1997160768 @default.
• W2095157185 cites W1999692723 @default.
• W2095157185 cites W2012582740 @default.
• W2095157185 cites W2021964708 @default.
• W2095157185 cites W2028436804 @default.
• W2095157185 cites W2031655994 @default.
• W2095157185 cites W2031906533 @default.
• W2095157185 cites W2045882821 @default.
• W2095157185 cites W2047487074 @default.
• W2095157185 cites W2048505725 @default.
• W2095157185 cites W2051737015 @default.
• W2095157185 cites W2068751176 @default.
• W2095157185 cites W2070091592 @default.
• W2095157185 cites W2073155558 @default.
• W2095157185 cites W2077688949 @default.
• W2095157185 cites W2084531845 @default.
• W2095157185 cites W2102343148 @default.
• W2095157185 cites W2107537187 @default.
• W2095157185 cites W2112519660 @default.
• W2095157185 cites W2129497119 @default.
• W2095157185 cites W2140928605 @default.
• W2095157185 cites W2141403362 @default.
• W2095157185 cites W2317946538 @default.
• W2095157185 cites W4234180827 @default.
• W2095157185 doi "https://doi.org/10.1001/jamaneurol.2014.3375" @default.
• W2095157185 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4397164" @default.
• W2095157185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25706191" @default.
• W2095157185 hasPublicationYear "2015" @default.
• W2095157185 type Work @default.
• W2095157185 sameAs 2095157185 @default.
• W2095157185 citedByCount "126" @default.
• W2095157185 countsByYear W20951571852015 @default.
• W2095157185 countsByYear W20951571852016 @default.
• W2095157185 countsByYear W20951571852017 @default.
• W2095157185 countsByYear W20951571852018 @default.
• W2095157185 countsByYear W20951571852019 @default.
• W2095157185 countsByYear W20951571852020 @default.
• W2095157185 countsByYear W20951571852021 @default.
• W2095157185 countsByYear W20951571852022 @default.
• W2095157185 countsByYear W20951571852023 @default.
• W2095157185 crossrefType "journal-article" @default.
• W2095157185 hasAuthorship W2095157185A5001795846 @default.
• W2095157185 hasAuthorship W2095157185A5030911639 @default.
• W2095157185 hasAuthorship W2095157185A5034225628 @default.
• W2095157185 hasAuthorship W2095157185A5056034076 @default.
• W2095157185 hasAuthorship W2095157185A5062039064 @default.
• W2095157185 hasAuthorship W2095157185A5074253440 @default.
• W2095157185 hasAuthorship W2095157185A5076768887 @default.
• W2095157185 hasAuthorship W2095157185A5081258864 @default.
• W2095157185 hasAuthorship W2095157185A5084568106 @default.
• W2095157185 hasBestOaLocation W20951571851 @default.
• W2095157185 hasConcept C118552586 @default.
• W2095157185 hasConcept C126322002 @default.
• W2095157185 hasConcept C14216870 @default.
• W2095157185 hasConcept C15744967 @default.
• W2095157185 hasConcept C169900460 @default.
• W2095157185 hasConcept C2779134260 @default.
• W2095157185 hasConcept C2779483572 @default.
• W2095157185 hasConcept C2780906993 @default.
• W2095157185 hasConcept C502032728 @default.
• W2095157185 hasConcept C535046627 @default.
• W2095157185 hasConcept C71924100 @default.
• W2095157185 hasConcept C74909509 @default.
• W2095157185 hasConceptScore W2095157185C118552586 @default.
• W2095157185 hasConceptScore W2095157185C126322002 @default.
• W2095157185 hasConceptScore W2095157185C14216870 @default.
• W2095157185 hasConceptScore W2095157185C15744967 @default.
• W2095157185 hasConceptScore W2095157185C169900460 @default.
• W2095157185 hasConceptScore W2095157185C2779134260 @default.
• W2095157185 hasConceptScore W2095157185C2779483572 @default.
• W2095157185 hasConceptScore W2095157185C2780906993 @default.
• W2095157185 hasConceptScore W2095157185C502032728 @default.
• W2095157185 hasConceptScore W2095157185C535046627 @default.
• W2095157185 hasConceptScore W2095157185C71924100 @default.
• W2095157185 hasConceptScore W2095157185C74909509 @default.
• W2095157185 hasIssue "4" @default.
• W2095157185 hasLocation W20951571851 @default.
• W2095157185 hasLocation W20951571852 @default.

• next