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- W2095160131 endingPage "20" @default.
- W2095160131 startingPage "3" @default.
- W2095160131 abstract "The histone deacetylase inhibitors (HDACi) have demonstrated anticancer efficacy across a range of malignancies, most impressively in the hematological cancers. It is uncertain whether this clinical efficacy is attributable predominantly to their ability to induce apoptosis and differentiation in the cancer cell, or to their ability to prime the cell to other pro-death stimuli such as those from the immune system. HDACi-induced apoptosis occurs through altered expression of genes encoding proteins in both intrinsic and extrinsic apoptotic pathways; through effects on the proteasome/aggresome systems; through the production of reactive oxygen species, possibly by directly inducing DNA damage; and through alterations in the tumor microenvironment. In addition HDACi increase the immunogenicity of tumor cells and modulate cytokine signaling and potentially T-cell polarization in ways that may contribute the anti-cancer effect in vivo. Here, we provide an overview of current thinking on the mechanisms of HDACi activity, with attention given to the hematological malignancies as well as scientific observations arising from the clinical trials. We also focus on the immune effects of these agents." @default.
- W2095160131 created "2016-06-24" @default.
- W2095160131 creator A5027391845 @default.
- W2095160131 creator A5031193094 @default.
- W2095160131 creator A5052829828 @default.
- W2095160131 date "2010-12-01" @default.
- W2095160131 modified "2023-10-18" @default.
- W2095160131 title "Histone deacetylase inhibitors: potential targets responsible for their anti-cancer effect" @default.
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