FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095160745> ?p ?o ?g. }

• W2095160745 endingPage "9" @default.
• W2095160745 startingPage "1" @default.
• W2095160745 abstract "Thrombosis is one of the major causes of human death worldwide. Identification of the cellular and molecular mechanisms leading to thrombus formation is thus crucial for the understanding of the thrombotic process. To examine thrombus formation in a living mouse, new technologies have been developed. Digital intravital microscopy allows to visualize the development of thrombosis and generation of fibrin in real-time within living animal in a physiological context. This specific system allowed the identification of new cellular partners involved in platelet adhesion and activation. Furthermore, it improved, especially, the knowledge of the early phase of thrombus formation and fibrin generation in vivo. Until now, platelets used to be considered the sole central player in thrombus generation. However, recently, it has been demonstrated that leukocytes, particularly neutrophils, play a crucial role in the activation of the blood coagulation cascade leading to thrombosis. In this review, we summarized the mechanisms leading to thrombus formation in the microcirculation according to the method of injury in mice with a special focus on the new identified roles of neutrophils in this process. La thrombose est l’une des causes majeures de mortalité dans le monde chez l’Homme. L’identification des mécanismes cellulaires et moléculaires impliqués dans la formation d’un thrombus est donc cruciale pour la compréhension du processus thrombotique. De nouvelles technologies ont été développées afin de modéliser le processus de thrombose in vivo. La microscopie digitale intravitale permet de visualiser en temps réel le développement d’un thrombus et la génération de fibrine dans l’animal vivant dans un contexte physiologique. Ce système spécifique permet l’identification de nouveaux partenaires impliqués dans l’adhésion et l’activation plaquettaire. De plus, la microscopie digitale intravitale en temps réel permet l’identification des différents partenaires impliqués dans les phases précoces de la formation d’un thrombus in vivo. Jusqu’à maintenant, les plaquettes étaient considérées comme les seuls partenaires majeurs jouant un rôle dans la formation d’un thrombus. Récemment, il a été démontré que les leucocytes, en particulier les neutrophiles, jouaient un rôle important dans l’activation de la cascade de coagulation menant à la formation d’un thrombus plaquettaire. Cette revue présente les mécanismes mis en jeu dans la formation d’un thrombus en fonction des différents modèles de blessure dans la microcirculation de la souris et décrit spécifiquement le rôle des neutrophiles dans la phase précoce de développement du thrombus." @default.
• W2095160745 created "2016-06-24" @default.
• W2095160745 creator A5018259733 @default.
• W2095160745 creator A5041763579 @default.
• W2095160745 creator A5046208454 @default.
• W2095160745 creator A5047868255 @default.
• W2095160745 creator A5078347615 @default.
• W2095160745 date "2014-02-01" @default.
• W2095160745 modified "2023-09-25" @default.
• W2095160745 title "Involvement of neutrophils in thrombus formation in living mice" @default.
• W2095160745 cites W1535821431 @default.
• W2095160745 cites W1538447709 @default.
• W2095160745 cites W1561516029 @default.
• W2095160745 cites W1597610606 @default.
• W2095160745 cites W1623022149 @default.
• W2095160745 cites W167520159 @default.
• W2095160745 cites W1811402656 @default.
• W2095160745 cites W1849821766 @default.
• W2095160745 cites W1959181807 @default.
• W2095160745 cites W1965740748 @default.
• W2095160745 cites W1966814073 @default.
• W2095160745 cites W1982213737 @default.
• W2095160745 cites W1983760732 @default.
• W2095160745 cites W1985975297 @default.
• W2095160745 cites W1991864560 @default.
• W2095160745 cites W1992573675 @default.
• W2095160745 cites W1994102351 @default.
• W2095160745 cites W1994749414 @default.
• W2095160745 cites W1996058648 @default.
• W2095160745 cites W1999517476 @default.
• W2095160745 cites W2001328992 @default.
• W2095160745 cites W2011070696 @default.
• W2095160745 cites W2011875550 @default.
• W2095160745 cites W2012002484 @default.
• W2095160745 cites W2013301732 @default.
• W2095160745 cites W2015877067 @default.
• W2095160745 cites W2016669482 @default.
• W2095160745 cites W2022069885 @default.
• W2095160745 cites W2023122926 @default.
• W2095160745 cites W2025015037 @default.
• W2095160745 cites W2027125446 @default.
• W2095160745 cites W2030455963 @default.
• W2095160745 cites W2031133385 @default.
• W2095160745 cites W2037863911 @default.
• W2095160745 cites W2038796948 @default.
• W2095160745 cites W2045819100 @default.
• W2095160745 cites W2046499889 @default.
• W2095160745 cites W2047118128 @default.
• W2095160745 cites W2049349163 @default.
• W2095160745 cites W2054540030 @default.
• W2095160745 cites W2054768484 @default.
• W2095160745 cites W2055584330 @default.
• W2095160745 cites W2057016253 @default.
• W2095160745 cites W2059812456 @default.
• W2095160745 cites W2062563200 @default.
• W2095160745 cites W2064693934 @default.
• W2095160745 cites W2066406269 @default.
• W2095160745 cites W2070117107 @default.
• W2095160745 cites W2074707530 @default.
• W2095160745 cites W2076887890 @default.
• W2095160745 cites W2080455788 @default.
• W2095160745 cites W2087411946 @default.
• W2095160745 cites W2092013656 @default.
• W2095160745 cites W2092330685 @default.
• W2095160745 cites W2092956019 @default.
• W2095160745 cites W2093201027 @default.
• W2095160745 cites W2095799155 @default.
• W2095160745 cites W2096668363 @default.
• W2095160745 cites W2098573845 @default.
• W2095160745 cites W2101155229 @default.
• W2095160745 cites W2102438459 @default.
• W2095160745 cites W2104380573 @default.
• W2095160745 cites W2104934425 @default.
• W2095160745 cites W2107817883 @default.
• W2095160745 cites W2112853332 @default.
• W2095160745 cites W2112909901 @default.
• W2095160745 cites W2124011290 @default.
• W2095160745 cites W2125762027 @default.
• W2095160745 cites W2126683943 @default.
• W2095160745 cites W2128054798 @default.
• W2095160745 cites W2128214001 @default.
• W2095160745 cites W2129464080 @default.
• W2095160745 cites W2137108685 @default.
• W2095160745 cites W2139812868 @default.
• W2095160745 cites W2142649232 @default.
• W2095160745 cites W2152502508 @default.
• W2095160745 cites W2152715857 @default.
• W2095160745 cites W2154699417 @default.
• W2095160745 cites W2161488081 @default.
• W2095160745 cites W2163170565 @default.
• W2095160745 cites W2168887400 @default.
• W2095160745 cites W2169481463 @default.
• W2095160745 cites W2170708401 @default.
• W2095160745 cites W2172191543 @default.
• W2095160745 cites W2184543707 @default.
• W2095160745 cites W2230724256 @default.
• W2095160745 cites W2250168035 @default.
• W2095160745 cites W2313774959 @default.

• next