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- W2095162152 abstract "Most schizophrenia patients have a deficit in auditory sensory gating, which appears to be mediated by the alpha-7 nicotinic receptor, that is not improved with conventional antipsychotic treatment. This study examined the effects of ondansetron, a highly selective 5-HT3 antagonist, on the P50 auditory evoked potential.Eight medicated outpatients with schizophrenia were given either ondansetron (16 mg) or placebo in a double-blind, placebo-controlled design. Evoked potentials were recorded at baseline and 1 hour, 2 hours, and 3 hours after receipt of drug.There was a highly significant improvement in P50 gating after ondansetron treatment. The maximal treatment difference was at 2 hours posttreatment (ondansetron: mean=41.4%, SD=39.7%; placebo: mean=80.2%, SD=21.3%).Ondansetron significantly enhanced P50 auditory gating in schizophrenia patients treated with typical antipsychotics." @default.
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- W2095162152 date "2005-02-01" @default.
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- W2095162152 title "Improved P50 Auditory Gating With Ondansetron in Medicated Schizophrenia Patients" @default.
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- W2095162152 doi "https://doi.org/10.1176/appi.ajp.162.2.386" @default.
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