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- W2095164493 abstract "Abstract Cold stress, phenobarbital and hydrocortisone treatment have been examined for their effects on microsomal drug metabolizing enzymes in the adrenalectomized rat. Adrenalectomy alone markedly reduces the rate of metabolism of ethylmorphine, aniline and hexobarbital. The administration of hydrocortisone or the exposure of adrenalectomized animals to cold stress results in an increase in ethylmorphine and aniline metabolism, but only a further decrease in the rate of hexobarbital metabolism. Phenobarbital stimulates the metabolism of all three compounds in adrenalectomized rats. These findings indicate that both stress and phenobarbital can bring about changes in drug metabolism independent of the presence of an intact adrenal. It is further suggested that phenobarbital and stress produce their changes in enzyme activity through different mechanisms since phenobarbital treatment results only in stimulatory activity while stress causes either an increase or a decrease depending upon the drug pathway examined. The possible role of extra-adrenal steroids mediating the stress-produced enzyme induction is discussed." @default.
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- W2095164493 date "1968-01-01" @default.
- W2095164493 modified "2023-10-05" @default.
- W2095164493 title "Stress-induced alterations in microsomal drug metabolism in the adrenalectomized rat" @default.
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- W2095164493 doi "https://doi.org/10.1016/0006-2952(68)90164-0" @default.
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