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• W2095165881 abstract "The risk assessment of di(2-ethylhexyl)phthalate (DEHP) migrating from polyvinyl chloride (PVC) medical devices is an important issue. Many studies have been conducted to determine the level of DEHP migration. A recent report has indicated that DEHP in blood bags is hydrolyzed by esterase into mono(2-ethylhexyl)phthalate (MEHP). However, MEHP is thought to be even more toxic than the parent compound. Therefore, a method for the simultaneous determination of DEHP and MEHP was developed. The limits of quantification (LOQs) of DEHP and MEHP were 2.5 and 0.75 ng/ml, respectively. In this study, the effect of sterilization process on the levels of DEHP and MEHP migration was investigated. The level of migration of DEHP from gamma(γ)-ray sterilized PVC sheet was low compared with that of the unsterilized control. By contrast, the level of MEHP migration from the γ-ray sterilized PVC sheet was high compared with that of the unsterilized control. In addition, a high content of MEHP was found in the γ-ray sterilized PVC sheet." @default.
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• W2095165881 date "2006-05-01" @default.
• W2095165881 modified "2023-09-23" @default.
• W2095165881 title "Effect of sterilization process on the formation of mono(2-ethylhexyl)phthalate from di(2-ethylhexyl)phthalate" @default.
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• W2095165881 doi "https://doi.org/10.1016/j.jpba.2005.12.021" @default.
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