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• W2095172017 abstract "Cardiomyocytes have a complex Ca(2+) behavior and changes in this behavior may underlie certain disease states. Intracellular Ca(2+) activity can be regulated by the phospholipase Cβ-Gα(q) pathway localized on the plasma membrane. The plasma membranes of cardiomycoytes are rich in caveolae domains organized by caveolin proteins. Caveolae may indirectly affect cell signals by entrapping and localizing specific proteins. Recently, we found that caveolin may specifically interact with activated Gα(q), which could affect Ca(2+) signals. Here, using fluorescence imaging and correlation techniques we show that Gα(q)-Gβγ subunits localize to caveolae in adult ventricular canine cardiomyoctyes. Carbachol stimulation releases Gβγ subunits from caveolae with a concurrent stabilization of activated Gα(q) by caveolin-3 (Cav3). These cells show oscillating Ca(2+) waves that are not seen in neonatal cells that do not contain Cav3. Microinjection of a peptide that disrupts Cav3-Gα(q) association, but not a control peptide, extinguishes the waves. Furthermore, these waves are unchanged with rynaodine treatment, but not seen with treatment of a phospholipase C inhibitor, implying that Cav3-Gα(q) is responsible for this Ca(2+) activity. Taken together, these studies show that caveolae play a direct and active role in regulating basal Ca(2+) activity in cardiomyocytes." @default.
• W2095172017 created "2016-06-24" @default.
• W2095172017 creator A5006740919 @default.
• W2095172017 creator A5032136628 @default.
• W2095172017 creator A5080995402 @default.
• W2095172017 date "2011-04-01" @default.
• W2095172017 modified "2023-09-27" @default.
• W2095172017 title "Modulation of Ca2+ Activity in Cardiomyocytes through Caveolae-Gαq Interactions" @default.
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• W2095172017 doi "https://doi.org/10.1016/j.bpj.2011.02.013" @default.
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