Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095181523> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2095181523 endingPage "265" @default.
- W2095181523 startingPage "260" @default.
- W2095181523 abstract "We have compared the cytotoxicity of exogenously added fatty acid (oleic acid) and that of endogenous free fatty acids released from cell membranes by phospholipase A2 in primary cultures of mouse proximal tubular (MPT) cells and in Madine-Darby canine kidney (MDCK) cells. Exposure of MPT cell monolayers to oleic acid (125 mmol/L) for 2 hours resulted in severe irreversible injury to 70% ± 4% of MPT cells. In striking contrast, only 8% ± 3% of MDCK cells were killed by the same insult. This striking difference in the response to exogenous oleate by MPT and MDCK cells was associated with modest and comparable reductions in cell adenosine triphosphate (ATP) content in both cell types. Chemical anoxia induced by cyanide plus deoxyglucose (CN-DOG) in the absence of glucose was associated with greater injury in MPT cells (45% ± 6% killed) than in MDCK cells (16% ± 5% cells killed) despite severe and comparable depletion of cell ATP content in both MPT cells (96.0% ± 0.6% reduction) and MDCK cells (96.0% ± 0.5% reduction). The release of endogenous fatty acids by the exposure of cells to exogenous phospholipase A2 caused mild injury in both cell types that was more severe in MPT cells than in MDCK cells. The combined insult of phospholipase A2 and chemical anoxia for 2 hours caused substantially greater cell injury in both MPT and MDCK cells than either intervention alone, but the combined insult was still more damaging to MPT cells (73% ± 4% killed) than to MDCK cells (30% ± 4% killed). We conclude that the cell membrane in MDCK cells is intrinsically more resistant to fatty acid-induced injury than the lipid membrane in MPT cells." @default.
- W2095181523 created "2016-06-24" @default.
- W2095181523 creator A5019968962 @default.
- W2095181523 creator A5053369590 @default.
- W2095181523 creator A5080643234 @default.
- W2095181523 date "1997-02-01" @default.
- W2095181523 modified "2023-10-15" @default.
- W2095181523 title "Fatty acid-induced cytotoxicity: Differences in susceptibility between mdck cells and primary cultures of proximal tubular cells" @default.
- W2095181523 cites W119453059 @default.
- W2095181523 cites W1528048556 @default.
- W2095181523 cites W1574033922 @default.
- W2095181523 cites W1967303417 @default.
- W2095181523 cites W1979501223 @default.
- W2095181523 cites W2008174213 @default.
- W2095181523 cites W2013372830 @default.
- W2095181523 cites W2019529403 @default.
- W2095181523 cites W2021772879 @default.
- W2095181523 cites W2024594571 @default.
- W2095181523 cites W2029554708 @default.
- W2095181523 cites W2035680779 @default.
- W2095181523 cites W2063123103 @default.
- W2095181523 cites W2081606516 @default.
- W2095181523 cites W2114051360 @default.
- W2095181523 cites W2127102931 @default.
- W2095181523 cites W2135474961 @default.
- W2095181523 cites W2153856379 @default.
- W2095181523 doi "https://doi.org/10.1016/s0022-2143(97)90148-7" @default.
- W2095181523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9016864" @default.
- W2095181523 hasPublicationYear "1997" @default.
- W2095181523 type Work @default.
- W2095181523 sameAs 2095181523 @default.
- W2095181523 citedByCount "7" @default.
- W2095181523 countsByYear W20951815232013 @default.
- W2095181523 countsByYear W20951815232016 @default.
- W2095181523 countsByYear W20951815232018 @default.
- W2095181523 crossrefType "journal-article" @default.
- W2095181523 hasAuthorship W2095181523A5019968962 @default.
- W2095181523 hasAuthorship W2095181523A5053369590 @default.
- W2095181523 hasAuthorship W2095181523A5080643234 @default.
- W2095181523 hasBestOaLocation W20951815231 @default.
- W2095181523 hasConcept C109316439 @default.
- W2095181523 hasConcept C12927208 @default.
- W2095181523 hasConcept C1491633281 @default.
- W2095181523 hasConcept C153911025 @default.
- W2095181523 hasConcept C16613235 @default.
- W2095181523 hasConcept C181199279 @default.
- W2095181523 hasConcept C185592680 @default.
- W2095181523 hasConcept C202751555 @default.
- W2095181523 hasConcept C2776551241 @default.
- W2095181523 hasConcept C543025807 @default.
- W2095181523 hasConcept C54355233 @default.
- W2095181523 hasConcept C55493867 @default.
- W2095181523 hasConcept C81885089 @default.
- W2095181523 hasConcept C86803240 @default.
- W2095181523 hasConceptScore W2095181523C109316439 @default.
- W2095181523 hasConceptScore W2095181523C12927208 @default.
- W2095181523 hasConceptScore W2095181523C1491633281 @default.
- W2095181523 hasConceptScore W2095181523C153911025 @default.
- W2095181523 hasConceptScore W2095181523C16613235 @default.
- W2095181523 hasConceptScore W2095181523C181199279 @default.
- W2095181523 hasConceptScore W2095181523C185592680 @default.
- W2095181523 hasConceptScore W2095181523C202751555 @default.
- W2095181523 hasConceptScore W2095181523C2776551241 @default.
- W2095181523 hasConceptScore W2095181523C543025807 @default.
- W2095181523 hasConceptScore W2095181523C54355233 @default.
- W2095181523 hasConceptScore W2095181523C55493867 @default.
- W2095181523 hasConceptScore W2095181523C81885089 @default.
- W2095181523 hasConceptScore W2095181523C86803240 @default.
- W2095181523 hasIssue "2" @default.
- W2095181523 hasLocation W20951815231 @default.
- W2095181523 hasLocation W20951815232 @default.
- W2095181523 hasOpenAccess W2095181523 @default.
- W2095181523 hasPrimaryLocation W20951815231 @default.
- W2095181523 hasRelatedWork W1968792623 @default.
- W2095181523 hasRelatedWork W2015942817 @default.
- W2095181523 hasRelatedWork W2036548555 @default.
- W2095181523 hasRelatedWork W2063900196 @default.
- W2095181523 hasRelatedWork W2081563803 @default.
- W2095181523 hasRelatedWork W2090821389 @default.
- W2095181523 hasRelatedWork W2121812021 @default.
- W2095181523 hasRelatedWork W2426048332 @default.
- W2095181523 hasRelatedWork W2470290674 @default.
- W2095181523 hasRelatedWork W4312799881 @default.
- W2095181523 hasVolume "129" @default.
- W2095181523 isParatext "false" @default.
- W2095181523 isRetracted "false" @default.
- W2095181523 magId "2095181523" @default.
- W2095181523 workType "article" @default.