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- W2095183775 abstract "In vivo study using a moderate spinal cord contusion injury (SCI) model in adult rat. To assess the immunomodulatory effects of the purine nucleoside inosine on macrophage/microglia activation at and near the lesion site and in white matter areas remote from the injury epicenter. Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY, USA. Animals (N=56) were injured using a moderate SCI at T9–T10 spinal level and were divided into three groups, depending on treatment paradigm. Rats received either intraperitoneal or subcutaneous injections of inosine (N=28) or vehicle (N=28). Spinal cord tissue was processed for ED-1 immunoreactivity and the volume fraction of ED-1+ profiles was calculated using the Cavalieri method and unbiased stereology. The volume fraction of ED-1+ profiles within gray and lateral white matter regions at and around the lesion site was significantly reduced only following a twice daily-6 week treatment course, compared with vehicle controls, and white matter areas remote from the lesion were unaffected by all inosine treatment paradigms. Continued subcutaneous delivery of inosine, beginning 15-min post-SCI and persisting throughout the survival period of 6 weeks exerted immunomodulatory effects at and around the lesion site." @default.
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- W2095183775 date "2007-04-03" @default.
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- W2095183775 title "Immunomodulatory effect of the purine nucleoside inosine following spinal cord contusion injury in rat" @default.
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- W2095183775 doi "https://doi.org/10.1038/sj.sc.3102057" @default.
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