FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095193585> ?p ?o ?g. }

• W2095193585 endingPage "93" @default.
• W2095193585 startingPage "90" @default.
• W2095193585 abstract "When encountering foreign antigens, naïve T cells become activated and differentiate into effector and memory T cells. They represent therefore the primary source to mount an immune response against pathogens or tumors. Recent evidence of both quantitative and qualitative alterations of naïve T cells has accumulated in aged mice, indicating that the successful generation of primary T cell responses from the naïve T cell pool may be compromised with old age. However, the vast majority of the data supporting compromised naïve T cell priming efficacy with old age have been produced in animal models, and the situation is much less clear in humans. In the elderly, the involution of the thymus and the associated decline in thymic output result in a decreased number of naïve T cells, which is partially compensated by homeostatic proliferation. Emerging evidence suggest that alterations of the TCR repertoire diversity and intrinsic defects of old CD4+ naïve T cells may impact on their responsiveness to antigenic stimulation. Increasing focus on the study of naïve T cells (in particular CD8+) in old humans are needed to fill the gaps in our understanding of reduced cellular immunity with aging." @default.
• W2095193585 created "2016-06-24" @default.
• W2095193585 creator A5044666153 @default.
• W2095193585 creator A5072720584 @default.
• W2095193585 date "2014-06-01" @default.
• W2095193585 modified "2023-09-29" @default.
• W2095193585 title "Naive T cells: The crux of cellular immune aging?" @default.
• W2095193585 cites W1480768075 @default.
• W2095193585 cites W1483721055 @default.
• W2095193585 cites W1554804861 @default.
• W2095193585 cites W1556334181 @default.
• W2095193585 cites W1578697340 @default.
• W2095193585 cites W1580217007 @default.
• W2095193585 cites W1603763228 @default.
• W2095193585 cites W1603918837 @default.
• W2095193585 cites W1652988747 @default.
• W2095193585 cites W1926141441 @default.
• W2095193585 cites W1931750338 @default.
• W2095193585 cites W1964741953 @default.
• W2095193585 cites W1985295562 @default.
• W2095193585 cites W1988073271 @default.
• W2095193585 cites W1988503573 @default.
• W2095193585 cites W1991601117 @default.
• W2095193585 cites W1992431343 @default.
• W2095193585 cites W1995716646 @default.
• W2095193585 cites W1996493196 @default.
• W2095193585 cites W1999924197 @default.
• W2095193585 cites W2009098629 @default.
• W2095193585 cites W2025664838 @default.
• W2095193585 cites W2025969211 @default.
• W2095193585 cites W2027434623 @default.
• W2095193585 cites W2036956793 @default.
• W2095193585 cites W2038219751 @default.
• W2095193585 cites W2042301753 @default.
• W2095193585 cites W2045387067 @default.
• W2095193585 cites W2054650629 @default.
• W2095193585 cites W2055311421 @default.
• W2095193585 cites W2069043306 @default.
• W2095193585 cites W2076219964 @default.
• W2095193585 cites W2079777226 @default.
• W2095193585 cites W2081208716 @default.
• W2095193585 cites W2089500922 @default.
• W2095193585 cites W2090958278 @default.
• W2095193585 cites W2094247899 @default.
• W2095193585 cites W2104601608 @default.
• W2095193585 cites W2105527855 @default.
• W2095193585 cites W2114468717 @default.
• W2095193585 cites W2124731139 @default.
• W2095193585 cites W2128629993 @default.
• W2095193585 cites W2140058614 @default.
• W2095193585 cites W2153331359 @default.
• W2095193585 cites W2153680933 @default.
• W2095193585 cites W2158968421 @default.
• W2095193585 cites W2163612602 @default.
• W2095193585 cites W2163782912 @default.
• W2095193585 doi "https://doi.org/10.1016/j.exger.2014.01.003" @default.
• W2095193585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24440387" @default.
• W2095193585 hasPublicationYear "2014" @default.
• W2095193585 type Work @default.
• W2095193585 sameAs 2095193585 @default.
• W2095193585 citedByCount "86" @default.
• W2095193585 countsByYear W20951935852014 @default.
• W2095193585 countsByYear W20951935852015 @default.
• W2095193585 countsByYear W20951935852016 @default.
• W2095193585 countsByYear W20951935852017 @default.
• W2095193585 countsByYear W20951935852018 @default.
• W2095193585 countsByYear W20951935852019 @default.
• W2095193585 countsByYear W20951935852020 @default.
• W2095193585 countsByYear W20951935852021 @default.
• W2095193585 countsByYear W20951935852022 @default.
• W2095193585 countsByYear W20951935852023 @default.
• W2095193585 crossrefType "journal-article" @default.
• W2095193585 hasAuthorship W2095193585A5044666153 @default.
• W2095193585 hasAuthorship W2095193585A5072720584 @default.
• W2095193585 hasConcept C100701293 @default.
• W2095193585 hasConcept C147483822 @default.
• W2095193585 hasConcept C154317977 @default.
• W2095193585 hasConcept C167672396 @default.
• W2095193585 hasConcept C169760540 @default.
• W2095193585 hasConcept C186720457 @default.
• W2095193585 hasConcept C19317047 @default.
• W2095193585 hasConcept C202751555 @default.
• W2095193585 hasConcept C203014093 @default.
• W2095193585 hasConcept C2775982045 @default.
• W2095193585 hasConcept C2776090121 @default.
• W2095193585 hasConcept C2777314012 @default.
• W2095193585 hasConcept C2777367678 @default.
• W2095193585 hasConcept C2781409172 @default.
• W2095193585 hasConcept C51785407 @default.
• W2095193585 hasConcept C54355233 @default.
• W2095193585 hasConcept C59822182 @default.
• W2095193585 hasConcept C63645605 @default.
• W2095193585 hasConcept C81444415 @default.
• W2095193585 hasConcept C86803240 @default.
• W2095193585 hasConcept C8891405 @default.
• W2095193585 hasConcept C95444343 @default.
• W2095193585 hasConceptScore W2095193585C100701293 @default.
• W2095193585 hasConceptScore W2095193585C147483822 @default.

• next