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- W2095194311 endingPage "1124" @default.
- W2095194311 startingPage "1116" @default.
- W2095194311 abstract "In this review, we examine how a subset of signal transduction cascades initiated by Mycobacterium tuberculosis (Mtb) infection modulates transcription mediated by the human immunodeficiency virus type 1 long terminal repeat (HIV-1 LTR). We describe two distinct phases of signaling that target transcription factors known to bind the HIV-1 LTR, and thus drive viral transcription and replication, in cells of the Mtb-infected host. First, Mtb-derived molecules, including cell wall components and DNA, interact with a number of host pattern recognition receptors. Second, cytokines and chemokines secreted in response to Mtb infection initiate signal transduction cascades through their cognate receptors. Given the variation in cell wall components among distinct clinical Mtb strains, the initial pattern recognition receptor interaction leading to direct LTR activation and differential cytokine and chemokine production is likely to be an important aspect of Mtb strain-specific regulation of HIV-1 transcription and replication. Improved understanding of these molecular mechanisms in the context of bacterial and host genetics should provide key insights into the accelerated viral replication and disease progression characteristic of HIV/TB coinfection." @default.
- W2095194311 created "2016-06-24" @default.
- W2095194311 creator A5004983287 @default.
- W2095194311 creator A5029547396 @default.
- W2095194311 creator A5057700369 @default.
- W2095194311 creator A5061083848 @default.
- W2095194311 date "2011-12-01" @default.
- W2095194311 modified "2023-10-16" @default.
- W2095194311 title "Arc of a Vicious Circle" @default.
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