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• W2095194980 startingPage "449" @default.
• W2095194980 abstract "Abstract The changes that occur in mammalian systems following trauma and sepsis, termed systemic inflammatory response syndrome, elicit major changes in carbohydrate, protein, and energy metabolism. When these events persist for too long they result in a severe depletion of lean body mass, multiple organ dysfunction, and eventually death. Nutritional supplementation has been investigated to offset the severe loss of protein, and recent evidence suggests that diets enriched in branched‐chain amino acids (BCAAs) may be especially beneficial. BCAAs are metabolized in two major steps that are differentially expressed in muscle and liver. In muscle, BCAAs are reversibly transaminated to the corresponding α ‐keto acids. For the complete degradation of BCAAs, the α ‐keto acids must travel to the liver to undergo oxidation. The liver, in contrast to muscle, does not significantly express the branched‐chain aminotransferase. Thus, BCAA degradation is under the joint control of both liver and muscle. Recent evidence suggests that in liver, BCAAs may perform signaling functions, more specifically via activation of mTOR (mammalian target of rapamycin) signaling pathway, influencing a wide variety of metabolic and synthetic functions, including protein translation, insulin signaling, and oxidative stress following severe injury and infection. However, understanding of the system‐wide effects of BCAAs that integrate both metabolic and signaling aspects is currently lacking. Further investigation in this respect will help rationalize the design and optimization of nutritional supplements containing BCAAs for critically ill patients. WIREs Syst Biol Med 2013, 5:449–460. doi: 10.1002/wsbm.1219 This article is categorized under: Biological Mechanisms > Metabolism Physiology > Mammalian Physiology in Health and Disease Translational, Genomic, and Systems Medicine > Translational Medicine" @default.
• W2095194980 created "2016-06-24" @default.
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• W2095194980 date "2013-03-29" @default.
• W2095194980 modified "2023-09-23" @default.
• W2095194980 title "Branched‐chain amino acid supplementation: impact on signaling and relevance to critical illness" @default.
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• W2095194980 cites W1979293635 @default.
• W2095194980 cites W1979772514 @default.
• W2095194980 cites W1980195461 @default.
• W2095194980 cites W1980929731 @default.
• W2095194980 cites W1982577527 @default.
• W2095194980 cites W1984990706 @default.
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• W2095194980 cites W1987582842 @default.
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• W2095194980 cites W1994023618 @default.
• W2095194980 cites W1998559329 @default.
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• W2095194980 cites W2005972141 @default.
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• W2095194980 cites W2079195246 @default.
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• W2095194980 doi "https://doi.org/10.1002/wsbm.1219" @default.
• W2095194980 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4482218" @default.
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