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• W2095203753 endingPage "1734" @default.
• W2095203753 startingPage "1727" @default.
• W2095203753 abstract "Abstract Several clinical studies done with intravenous immunoglobulin (IVIg)–treated autoimmune patients as well as several in vitro studies have revealed that IVIg can reduce polyclonal T-cell activation and modify their cytokine secretion pattern. However, their effect on (auto)antigen-specific T-cell responses has never been addressed directly. In the present work, we used an in vivo model of induction of antigen-specific T-cell responses and an in vitro antigen presentation system to study the effects of IVIg on T-cell responses. The results obtained showed that IVIg inhibited both the in vivo and in vitro antigen-specific T-cell responses but that this effect was the indirect consequence of a reduction in the antigen presentation ability of antigen-presenting cells. The inhibitory effect of IVIg was FcγRIIb-independent, suggesting that IVIg must interfere with activating FcγRs expressed on antigen-presenting cells to reduce their ability to present antigens. Such inhibition of T-cell responses by reducing antigen presentation may therefore contribute to the well-known anti-inflammatory effects of IVIg in autoimmune diseases." @default.
• W2095203753 created "2016-06-24" @default.
• W2095203753 creator A5017504651 @default.
• W2095203753 creator A5057947476 @default.
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• W2095203753 date "2010-03-04" @default.
• W2095203753 modified "2023-10-01" @default.
• W2095203753 title "Indirect inhibition of in vivo and in vitro T-cell responses by intravenous immunoglobulins due to impaired antigen presentation" @default.
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• W2095203753 doi "https://doi.org/10.1182/blood-2009-06-225417" @default.
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