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• W2095216564 abstract "The effect of ethanol (10-500 mmol/l) on platelet thromboxane production and on vascular thromboxane and prostacyclin was studied in human fetal tissues. The release of thromboxane B2 (a metabolite of thromboxane A2) during thrombin-induced spontaneous aggregation of fetal platelets was inhibited by ethanol concentrations of 50 mmol/l or higher. Ethanol at concentration from 100 mmol/l also inhibited umbilical artery production of thromboxane B2 and that of 6-keto-prostaglandin F1 alpha (a metabolite of prostacyclin). However, it stimulated the conversion of exogenous arachidonic acid to thromboxane B2 in fetal platelets and to 6-keto-prostaglandin F1 alpha in the umbilical artery. This suggests that ethanol inhibits phospholipase A2, but stimulates the enzymes distal from phospholipase A2 in the prostaglandin-synthesizing enzyme cascade." @default.
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• W2095216564 date "1987-07-01" @default.
• W2095216564 modified "2023-09-26" @default.
• W2095216564 title "Effect of ethanol on thromboxane and prostacyclin synthesis by fetal platelets and umbilical artery" @default.
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• W2095216564 doi "https://doi.org/10.1016/0024-3205(87)90162-7" @default.
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