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- W2095221014 abstract "Redox balance underlies cellular homeostasis. Cancer initiation and progression has been linked to the disruption of redox balance and oxidative stress. Recent findings exemplify the distinctive roles of intracellular and extracellular redox state in the etiology and maintenance of oxidative stress associated with malignancy and metastasis. Within these compartments, redox sensitive cysteines play a crucial role in regulating cell signaling events that act to promote the malignant phenotype via the activation of survival pathways, disruption of cell-death signaling, and increases in cell proliferation. New approaches that aim to accurately evaluate subcellular and microenvironment redox potential may be useful in developing cancer diagnostics and therapeutics." @default.
- W2095221014 created "2016-06-24" @default.
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- W2095221014 date "2010-08-01" @default.
- W2095221014 modified "2023-10-16" @default.
- W2095221014 title "Redox metabolism and malignancy" @default.
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- W2095221014 doi "https://doi.org/10.1016/j.coph.2010.05.003" @default.
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