FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095222012> ?p ?o ?g. }

• W2095222012 endingPage "156" @default.
• W2095222012 startingPage "153" @default.
• W2095222012 abstract "Study objective: To compare the degree of improvement in pulmonary function achieved with recombinant human DNase I (rhDNase) administered by three different aerosol delivery systems: DeVilbiss Pulmo-Aide compressor with the Marquest Acorn II nebulizer, the Hudson T Up-draft nebulizer, and the Pari LC Jet Plus nebulizer with the Pari Inhalier Boy compressor. These produce similar aerosols in vitro in terms of size distribution and activity of delivered rhDNase. Study design: Multicenter, randomized, open-label, parallel-group comparison of changes from baseline in pulmonary function variables in each test group. Patients were treated with rhDNase (2.5 mg bid) for 15 days, administered with three different aerosol delivery systems. Setting: Outpatient clinics at 26 sites in the United States. Patients: 397 patients >5 years of age with cystic fibrosis and baseline forced vital capacity (FVC) values between 40 and 70% of predicted values. Results: All three nebulizers gave comparable improvements in pulmonary function. FEV1 increased by an average of 13.2 to 14.1%, FVC by 10.9 to 11.8%, and forced midexpiratory flow (FEF25-75) by 16.5 to 17.1%. No unusual or unexpected adverse events were reported other than those that would be expected in patients with cystic fibrosis. Conclusions: Recombinant human DNase I produced a similar magnitude of improvement in the pulmonary function of patients with cystic fibrosis when the drug was administered using three different types of nebulizer systems with similar in vitro delivery and safety characteristics. Study objective: To compare the degree of improvement in pulmonary function achieved with recombinant human DNase I (rhDNase) administered by three different aerosol delivery systems: DeVilbiss Pulmo-Aide compressor with the Marquest Acorn II nebulizer, the Hudson T Up-draft nebulizer, and the Pari LC Jet Plus nebulizer with the Pari Inhalier Boy compressor. These produce similar aerosols in vitro in terms of size distribution and activity of delivered rhDNase. Study design: Multicenter, randomized, open-label, parallel-group comparison of changes from baseline in pulmonary function variables in each test group. Patients were treated with rhDNase (2.5 mg bid) for 15 days, administered with three different aerosol delivery systems. Setting: Outpatient clinics at 26 sites in the United States. Patients: 397 patients >5 years of age with cystic fibrosis and baseline forced vital capacity (FVC) values between 40 and 70% of predicted values. Results: All three nebulizers gave comparable improvements in pulmonary function. FEV1 increased by an average of 13.2 to 14.1%, FVC by 10.9 to 11.8%, and forced midexpiratory flow (FEF25-75) by 16.5 to 17.1%. No unusual or unexpected adverse events were reported other than those that would be expected in patients with cystic fibrosis. Conclusions: Recombinant human DNase I produced a similar magnitude of improvement in the pulmonary function of patients with cystic fibrosis when the drug was administered using three different types of nebulizer systems with similar in vitro delivery and safety characteristics." @default.
• W2095222012 created "2016-06-24" @default.
• W2095222012 creator A5014095292 @default.
• W2095222012 creator A5027365112 @default.
• W2095222012 creator A5031137742 @default.
• W2095222012 creator A5056500136 @default.
• W2095222012 creator A5081740012 @default.
• W2095222012 date "1995-07-01" @default.
• W2095222012 modified "2023-09-23" @default.
• W2095222012 title "Comparison of Three Jet Nebulizer Aerosol Delivery Systems Used to Administer Recombinant Human DNase I to Patients With Cystic Fibrosis" @default.
• W2095222012 cites W140093203 @default.
• W2095222012 cites W1997182007 @default.
• W2095222012 cites W2023546954 @default.
• W2095222012 cites W2079682800 @default.
• W2095222012 cites W2117131869 @default.
• W2095222012 cites W2150399236 @default.
• W2095222012 cites W2333398204 @default.
• W2095222012 cites W4244598283 @default.
• W2095222012 cites W4249200669 @default.
• W2095222012 doi "https://doi.org/10.1378/chest.108.1.153" @default.
• W2095222012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7606951" @default.
• W2095222012 hasPublicationYear "1995" @default.
• W2095222012 type Work @default.
• W2095222012 sameAs 2095222012 @default.
• W2095222012 citedByCount "44" @default.
• W2095222012 countsByYear W20952220122012 @default.
• W2095222012 countsByYear W20952220122013 @default.
• W2095222012 countsByYear W20952220122014 @default.
• W2095222012 countsByYear W20952220122016 @default.
• W2095222012 countsByYear W20952220122018 @default.
• W2095222012 countsByYear W20952220122020 @default.
• W2095222012 countsByYear W20952220122021 @default.
• W2095222012 countsByYear W20952220122022 @default.
• W2095222012 countsByYear W20952220122023 @default.
• W2095222012 crossrefType "journal-article" @default.
• W2095222012 hasAuthorship W2095222012A5014095292 @default.
• W2095222012 hasAuthorship W2095222012A5027365112 @default.
• W2095222012 hasAuthorship W2095222012A5031137742 @default.
• W2095222012 hasAuthorship W2095222012A5056500136 @default.
• W2095222012 hasAuthorship W2095222012A5081740012 @default.
• W2095222012 hasConcept C126322002 @default.
• W2095222012 hasConcept C165637977 @default.
• W2095222012 hasConcept C197934379 @default.
• W2095222012 hasConcept C2776938444 @default.
• W2095222012 hasConcept C2776954882 @default.
• W2095222012 hasConcept C2777714996 @default.
• W2095222012 hasConcept C2780352487 @default.
• W2095222012 hasConcept C3018587741 @default.
• W2095222012 hasConcept C42219234 @default.
• W2095222012 hasConcept C55520419 @default.
• W2095222012 hasConcept C71924100 @default.
• W2095222012 hasConcept C75603125 @default.
• W2095222012 hasConceptScore W2095222012C126322002 @default.
• W2095222012 hasConceptScore W2095222012C165637977 @default.
• W2095222012 hasConceptScore W2095222012C197934379 @default.
• W2095222012 hasConceptScore W2095222012C2776938444 @default.
• W2095222012 hasConceptScore W2095222012C2776954882 @default.
• W2095222012 hasConceptScore W2095222012C2777714996 @default.
• W2095222012 hasConceptScore W2095222012C2780352487 @default.
• W2095222012 hasConceptScore W2095222012C3018587741 @default.
• W2095222012 hasConceptScore W2095222012C42219234 @default.
• W2095222012 hasConceptScore W2095222012C55520419 @default.
• W2095222012 hasConceptScore W2095222012C71924100 @default.
• W2095222012 hasConceptScore W2095222012C75603125 @default.
• W2095222012 hasIssue "1" @default.
• W2095222012 hasLocation W20952220121 @default.
• W2095222012 hasLocation W20952220122 @default.
• W2095222012 hasOpenAccess W2095222012 @default.
• W2095222012 hasPrimaryLocation W20952220121 @default.
• W2095222012 hasRelatedWork W1970639481 @default.
• W2095222012 hasRelatedWork W1996506769 @default.
• W2095222012 hasRelatedWork W2005806130 @default.
• W2095222012 hasRelatedWork W2027494131 @default.
• W2095222012 hasRelatedWork W2093946956 @default.
• W2095222012 hasRelatedWork W2127276460 @default.
• W2095222012 hasRelatedWork W2129772791 @default.
• W2095222012 hasRelatedWork W2164667934 @default.
• W2095222012 hasRelatedWork W4213362460 @default.
• W2095222012 hasRelatedWork W181376331 @default.
• W2095222012 hasVolume "108" @default.
• W2095222012 isParatext "false" @default.
• W2095222012 isRetracted "false" @default.
• W2095222012 magId "2095222012" @default.
• W2095222012 workType "article" @default.