Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095224095> ?p ?o ?g. }
- W2095224095 endingPage "76" @default.
- W2095224095 startingPage "63" @default.
- W2095224095 abstract "Increasing numbers of experimental investigations and recently also of clinical trials strongly suggest an integral involvement of the endothelin (ET)-system in the pathophysiology of a variety of disease states, mainly of the cardiovascular system. Ambrisentan (LU 208075), a selective ET(A)-receptor antagonist, is an orally active diphenyl propionic acid derivative. It has been shown to have a very promising efficacy to safety ratio in the initial clinical trials. Phase II and Phase III trials with ambrisentan in pulmonary arterial hypertension have been performed. The pharmacological properties and data from the experimental investigations suggest additional possible uses of ambrisentan in the prevention of reperfusion injury after organ transplantation and in restenosis following coronary artery dilatation. Furthermore, the pharmacological profile of ambrisentan indicates that this drug may also be suitable in the treatment of cerebrovascular disorders. In the present article basic investigations, animal studies and clinical trials with ambrisentan are reviewed. This review may help to define pathophysiological conditions, in which ambrisentan could be indicated and further evaluated in appropriate preclinical and clinical trials." @default.
- W2095224095 created "2016-06-24" @default.
- W2095224095 creator A5024876270 @default.
- W2095224095 creator A5075817512 @default.
- W2095224095 date "2006-03-01" @default.
- W2095224095 modified "2023-09-29" @default.
- W2095224095 title "Ambrisentan, a Non-peptide Endothelin Receptor Antagonist" @default.
- W2095224095 cites W14647281 @default.
- W2095224095 cites W1542205514 @default.
- W2095224095 cites W165024946 @default.
- W2095224095 cites W18749133 @default.
- W2095224095 cites W1964869550 @default.
- W2095224095 cites W1965171075 @default.
- W2095224095 cites W1967603758 @default.
- W2095224095 cites W1973969997 @default.
- W2095224095 cites W1975145271 @default.
- W2095224095 cites W1976158695 @default.
- W2095224095 cites W1983184640 @default.
- W2095224095 cites W1987634415 @default.
- W2095224095 cites W1989391725 @default.
- W2095224095 cites W1991469545 @default.
- W2095224095 cites W1992152322 @default.
- W2095224095 cites W1992748382 @default.
- W2095224095 cites W1995736390 @default.
- W2095224095 cites W1999150579 @default.
- W2095224095 cites W2003055862 @default.
- W2095224095 cites W2006230387 @default.
- W2095224095 cites W2009409333 @default.
- W2095224095 cites W2016374074 @default.
- W2095224095 cites W2016552483 @default.
- W2095224095 cites W2021511466 @default.
- W2095224095 cites W2023319500 @default.
- W2095224095 cites W2024884563 @default.
- W2095224095 cites W2027115021 @default.
- W2095224095 cites W2027472953 @default.
- W2095224095 cites W2028525203 @default.
- W2095224095 cites W2030804669 @default.
- W2095224095 cites W2033557350 @default.
- W2095224095 cites W2036574042 @default.
- W2095224095 cites W2038450148 @default.
- W2095224095 cites W2045843026 @default.
- W2095224095 cites W2051813950 @default.
- W2095224095 cites W2054177388 @default.
- W2095224095 cites W2062740984 @default.
- W2095224095 cites W2063474013 @default.
- W2095224095 cites W2066971646 @default.
- W2095224095 cites W2071201445 @default.
- W2095224095 cites W2076804216 @default.
- W2095224095 cites W2077566631 @default.
- W2095224095 cites W2078691028 @default.
- W2095224095 cites W2078977431 @default.
- W2095224095 cites W2079621143 @default.
- W2095224095 cites W2084874258 @default.
- W2095224095 cites W2087145277 @default.
- W2095224095 cites W2093306194 @default.
- W2095224095 cites W2100283402 @default.
- W2095224095 cites W2102283127 @default.
- W2095224095 cites W2105451684 @default.
- W2095224095 cites W2115537569 @default.
- W2095224095 cites W2117259028 @default.
- W2095224095 cites W2117587493 @default.
- W2095224095 cites W2118846800 @default.
- W2095224095 cites W2124600093 @default.
- W2095224095 cites W2128919501 @default.
- W2095224095 cites W2129137900 @default.
- W2095224095 cites W2138091764 @default.
- W2095224095 cites W2144128868 @default.
- W2095224095 cites W2147853442 @default.
- W2095224095 cites W2148013432 @default.
- W2095224095 cites W2148894324 @default.
- W2095224095 cites W2151869895 @default.
- W2095224095 cites W2153279775 @default.
- W2095224095 cites W2156677191 @default.
- W2095224095 cites W2157335732 @default.
- W2095224095 cites W2162804111 @default.
- W2095224095 cites W2166811364 @default.
- W2095224095 cites W2169631816 @default.
- W2095224095 cites W2313813711 @default.
- W2095224095 cites W2332169446 @default.
- W2095224095 cites W2334993432 @default.
- W2095224095 cites W2336346210 @default.
- W2095224095 cites W2417448419 @default.
- W2095224095 cites W2417891940 @default.
- W2095224095 cites W2435706037 @default.
- W2095224095 cites W4229938808 @default.
- W2095224095 cites W4243327937 @default.
- W2095224095 cites W4251755402 @default.
- W2095224095 cites W99062900 @default.
- W2095224095 doi "https://doi.org/10.1111/j.1527-3466.2006.00063.x" @default.
- W2095224095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16939634" @default.
- W2095224095 hasPublicationYear "2006" @default.
- W2095224095 type Work @default.
- W2095224095 sameAs 2095224095 @default.
- W2095224095 citedByCount "61" @default.
- W2095224095 countsByYear W20952240952012 @default.
- W2095224095 countsByYear W20952240952013 @default.
- W2095224095 countsByYear W20952240952014 @default.
- W2095224095 countsByYear W20952240952015 @default.