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• W2095225890 abstract "A chemoselective reaction between oxyamines and unprotected, unactivated reducing sugars was used to construct for the first time a panel of linkage-diversified neoglycosides. This panel of digitoxin analogs included potent and selective tumor cytotoxins; cytotoxicity was dependent on the structure of the glycosidic linkage. These results validate linkage diversification through neoglycosylation as a unique and simple strategy to powerfully complement existing methods for the optimization of glycoconjugates." @default.
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• W2095225890 date "2008-01-01" @default.
• W2095225890 modified "2023-09-27" @default.
• W2095225890 title "Modifying the glycosidic linkage in digitoxin analogs provides selective cytotoxins" @default.
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• W2095225890 doi "https://doi.org/10.1016/j.bmcl.2007.11.058" @default.
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