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• W2095231313 abstract "Low-density lipoprotein apheresis retards the progression of hyperlipidemic overt diabetic nephropathy.BackgroundHyperlipidemia has recently received attention as being involved in the progression of diabetic nephropathy (DN). Low-density lipoprotein apheresis (LDL-A) can remove a large amount of plasma lipid directly from the patients in a short time.MethodsFifteen type 2 diabetic patients with overt nephropathy received LDL-A in two different manners: short-term intensive therapy (SIT) for nine patients and long-term intermittent therapy (LIT) for six patients.ResultsThe changes in the monthly decline rates of reciprocal serum creatinine (1/Cr) were -0.035 ± 0.020 in the three-month period before SIT, 0.047 ± 0.041 during and until two weeks after SIT, and -0.035 ± 0.015 after a period of two weeks from the therapy. The mean duration of LIT in six patients was 8.2 ± 7.4 months, and the mean monthly decline rates of 1/Cr significantly decreased during the period of LIT as compared with the six-month period before the treatment.ConclusionLDL-A can retard the progression of overt DN, especially when it is performed repeatedly for a long period at two-week intervals. Low-density lipoprotein apheresis retards the progression of hyperlipidemic overt diabetic nephropathy. Hyperlipidemia has recently received attention as being involved in the progression of diabetic nephropathy (DN). Low-density lipoprotein apheresis (LDL-A) can remove a large amount of plasma lipid directly from the patients in a short time. Fifteen type 2 diabetic patients with overt nephropathy received LDL-A in two different manners: short-term intensive therapy (SIT) for nine patients and long-term intermittent therapy (LIT) for six patients. The changes in the monthly decline rates of reciprocal serum creatinine (1/Cr) were -0.035 ± 0.020 in the three-month period before SIT, 0.047 ± 0.041 during and until two weeks after SIT, and -0.035 ± 0.015 after a period of two weeks from the therapy. The mean duration of LIT in six patients was 8.2 ± 7.4 months, and the mean monthly decline rates of 1/Cr significantly decreased during the period of LIT as compared with the six-month period before the treatment. LDL-A can retard the progression of overt DN, especially when it is performed repeatedly for a long period at two-week intervals." @default.
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• W2095231313 date "1999-07-01" @default.
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• W2095231313 title "Low-density lipoprotein apheresis retards the progression of hyperlipidemic overt diabetic nephropathy" @default.
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• W2095231313 doi "https://doi.org/10.1046/j.1523-1755.1999.07153.x" @default.
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