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• W2095231337 endingPage "22" @default.
• W2095231337 startingPage "9" @default.
• W2095231337 abstract "Connexins are protein subunits that oligomerize into hexamers called connexons, gap junction hemichannels or just hemichannels. Because some gap junction channels are permeable to negatively and/or positively charged molecules up to approximately 1kDa in size, it was thought that hemichannels should not open to the extracellular space. A growing amount of evidence indicates that opening of hemichannels does occur under both physiological and pathological conditions in astrocytes and other cell types. Electrophysiological studies indicate that hemichannels have a low open probability under physiological conditions but may have a much higher open probability under certain pathological conditions. Some of the physiological behaviours of astrocytes that have been attributed to gap junctions may, in fact, be mediated by hemichannels. Hemichannels constituted of Cx43, the main connexin expressed by astrocytes, are permeable to small physiologically significant molecules, such as ATP, NAD+ and glutamate, and may mediate paracrine as well as autocrine signalling. Hemichannels tend to be closed by negative membrane potentials, high concentrations of extracellular Ca2+ and intracellular H+ ions, gap junction blockers and protein phosphorylation. Hemichannels tend to be opened by positive membrane potentials and low extracellular Ca2+, and possibly by as yet unidentified cytoplasmic signalling molecules. Exacerbated hemichannel opening occurs in metabolically inhibited cells, including cortical astrocytes, which contributes to the loss of chemical gradients across the plasma membrane and speeds cell death." @default.
• W2095231337 created "2016-06-24" @default.
• W2095231337 creator A5000929569 @default.
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• W2095231337 creator A5006044985 @default.
• W2095231337 creator A5009773603 @default.
• W2095231337 creator A5023550499 @default.
• W2095231337 date "2003-08-26" @default.
• W2095231337 modified "2023-10-18" @default.
• W2095231337 title "Gap junction hemichannels in astrocytes of the CNS" @default.
• W2095231337 cites W110247893 @default.
• W2095231337 cites W127258876 @default.
• W2095231337 cites W1509313163 @default.
• W2095231337 cites W1517261517 @default.
• W2095231337 cites W1529341137 @default.
• W2095231337 cites W1559657035 @default.
• W2095231337 cites W1563323538 @default.
• W2095231337 cites W1580586916 @default.
• W2095231337 cites W1592198449 @default.
• W2095231337 cites W1593655973 @default.
• W2095231337 cites W1595178772 @default.
• W2095231337 cites W1601294546 @default.
• W2095231337 cites W1605025912 @default.
• W2095231337 cites W1648606954 @default.
• W2095231337 cites W1753443034 @default.
• W2095231337 cites W1766687629 @default.
• W2095231337 cites W1860326127 @default.
• W2095231337 cites W1914765280 @default.
• W2095231337 cites W1925508137 @default.
• W2095231337 cites W1943019773 @default.
• W2095231337 cites W1950685957 @default.
• W2095231337 cites W1963680371 @default.
• W2095231337 cites W1969161489 @default.
• W2095231337 cites W1970011211 @default.
• W2095231337 cites W1970959286 @default.
• W2095231337 cites W1971070905 @default.
• W2095231337 cites W1972797509 @default.
• W2095231337 cites W1975979472 @default.
• W2095231337 cites W1977015296 @default.
• W2095231337 cites W1978344422 @default.
• W2095231337 cites W1981919734 @default.
• W2095231337 cites W1982524452 @default.
• W2095231337 cites W1983612345 @default.
• W2095231337 cites W1985155506 @default.
• W2095231337 cites W1987508789 @default.
• W2095231337 cites W1988316236 @default.
• W2095231337 cites W1990623062 @default.
• W2095231337 cites W1991706051 @default.
• W2095231337 cites W1992689315 @default.
• W2095231337 cites W1993191579 @default.
• W2095231337 cites W1993755617 @default.
• W2095231337 cites W1994144781 @default.
• W2095231337 cites W1994416969 @default.
• W2095231337 cites W1996081066 @default.
• W2095231337 cites W1996272414 @default.
• W2095231337 cites W1997215245 @default.
• W2095231337 cites W1997406039 @default.
• W2095231337 cites W1997899631 @default.
• W2095231337 cites W1998621313 @default.
• W2095231337 cites W2001851023 @default.
• W2095231337 cites W2002942271 @default.
• W2095231337 cites W2004448188 @default.
• W2095231337 cites W2004652628 @default.
• W2095231337 cites W2004915376 @default.
• W2095231337 cites W2005655563 @default.
• W2095231337 cites W2007854449 @default.
• W2095231337 cites W2007870366 @default.
• W2095231337 cites W2007910408 @default.
• W2095231337 cites W2008519469 @default.
• W2095231337 cites W2009307383 @default.
• W2095231337 cites W2009849990 @default.
• W2095231337 cites W2011049984 @default.
• W2095231337 cites W2011706581 @default.
• W2095231337 cites W2011908808 @default.
• W2095231337 cites W2012987253 @default.
• W2095231337 cites W2013366618 @default.
• W2095231337 cites W2013736577 @default.
• W2095231337 cites W2015169927 @default.
• W2095231337 cites W2015595997 @default.
• W2095231337 cites W2015820951 @default.
• W2095231337 cites W2016798725 @default.
• W2095231337 cites W2017907028 @default.
• W2095231337 cites W2017932524 @default.
• W2095231337 cites W2020486165 @default.
• W2095231337 cites W2021241421 @default.
• W2095231337 cites W2021879636 @default.
• W2095231337 cites W2022263881 @default.
• W2095231337 cites W2023550765 @default.
• W2095231337 cites W2024683202 @default.
• W2095231337 cites W2025106506 @default.
• W2095231337 cites W2027122653 @default.
• W2095231337 cites W2028120904 @default.
• W2095231337 cites W2032045111 @default.
• W2095231337 cites W2032962887 @default.
• W2095231337 cites W2034556040 @default.
• W2095231337 cites W2036455407 @default.
• W2095231337 cites W2038109343 @default.
• W2095231337 cites W2038418957 @default.

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