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• W2095238505 startingPage "92" @default.
• W2095238505 abstract "The goal of the study was to test the validity of additive versus synergistic versus underadditive versions of brain reserve theory within the context of HIV/AIDS. In addition, it tested the convergent validity of 2 operational definitions of premorbid reserve: verbal IQ (VIQ) and a family history (FH) of substance abuse or dependence. Seventy HIV-1 seronegative and 115 HIV-1 seropositive male and female volunteers were assigned to 4 subgroups defined by the crossing of a VIQ score < versus ≥ 90 with the presence versus absence of a paternal history of alcohol, cocaine, or opiate abuse or dependence. The principal dependent measure was the P300 event related brain potential elicited during the Stroop color-word interference task. The principal finding was an underadditive effect of FH plus HIV/AIDS on P300 area over the frontal region: FH reduced frontal scalp P300 to such a degree that the additional effects of HIV/AIDS were blunted. The alternate operational definition of brain reserve, VIQ, had no effect on P300 and did not alter the effects of HIV/AIDS. Familial risk for substance dependence and low VIQ compromise different aspects of brain structure and/or function and therefore differ in their relationship to HIV/AIDS and P300. Genetic differences associated with familial risk may reduce brain reserve to such a degree that the neurophysiological effects of HIV/AIDS can no longer be measured." @default.
• W2095238505 created "2016-06-24" @default.
• W2095238505 creator A5007490737 @default.
• W2095238505 date "2008-04-01" @default.
• W2095238505 modified "2023-09-27" @default.
• W2095238505 title "The effects of HIV on P300 are moderated by familial risk for substance dependence: Implications for a theory of brain reserve" @default.
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• W2095238505 doi "https://doi.org/10.1016/j.drugalcdep.2007.10.012" @default.
• W2095238505 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2270611" @default.
• W2095238505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18065165" @default.
• W2095238505 hasPublicationYear "2008" @default.
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