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- W2095244962 endingPage "29" @default.
- W2095244962 startingPage "22" @default.
- W2095244962 abstract "Fibroblast growth factors (FGFs) 15/19 and 21 belong to a subfamily of FGFs that function as hormones. Produced in response to specific nutritional cues, they act on overlapping sets of cell surface receptors composed of classic FGF receptors in complex with βKlotho, and regulate metabolism and related processes during periods of fluctuating energy availability. Pharmacologically, both FGF15/19 and FGF21 cause weight loss and improve both insulin-sensitivity and lipid parameters in rodent and primate models of metabolic disease. Recently, FGF21 was shown to have similar effects in obese patients with type 2 diabetes. We discuss here emerging concepts in FGF15/19 and FGF21 tissue-specific actions and critically assess their putative role as candidate targets for treating metabolic disease." @default.
- W2095244962 created "2016-06-24" @default.
- W2095244962 creator A5010352902 @default.
- W2095244962 creator A5023246864 @default.
- W2095244962 creator A5027432256 @default.
- W2095244962 date "2015-01-01" @default.
- W2095244962 modified "2023-10-11" @default.
- W2095244962 title "Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21" @default.
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