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- W2095254913 abstract "The discovery of the endogenous cannabimimetic lipid mediators, anandamide and 2-arachidonoyl glycerol, opened the door to the discovery of other endogenous lipid mediators similar in structure and function. The majority of these compounds do not bind appreciably to known cannabinoid receptors; yet some of them produce cannabimimetic effects while others exert actions through novel mechanisms that remain to be elucidated. This review explores the growing diversity of recently discovered putative lipid mediators and their relationship to the endogenous cannabinoid system. The possibility that there remain many unidentified signalling lipids coupled with the evidence that many of these yield bioactive metabolites due to actions of known enzymes (e.g. cyclooxygenases, lipoxygenases, cytochrome P450s) suggests the existence of a large and complex family of lipid mediators about which only little is known at this time. The elucidation of the biochemistry and pharmacology of these compounds may provide therapeutic targets for a variety of conditions including sleep dysfunction, eating disorders, cardiovascular disease, as well as inflammation and pain." @default.
- W2095254913 created "2016-06-24" @default.
- W2095254913 creator A5037892789 @default.
- W2095254913 creator A5086234142 @default.
- W2095254913 date "2005-02-01" @default.
- W2095254913 modified "2023-10-14" @default.
- W2095254913 title "The expanding field of cannabimimetic and related lipid mediators" @default.
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- W2095254913 doi "https://doi.org/10.1038/sj.bjp.0706093" @default.
- W2095254913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1576036" @default.
- W2095254913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15655504" @default.
- W2095254913 hasPublicationYear "2005" @default.
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