Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095272173> ?p ?o ?g. }
- W2095272173 endingPage "2392" @default.
- W2095272173 startingPage "2387" @default.
- W2095272173 abstract "We introduced disulfide bonds to lock the integrin alphaLbeta2 I domain in predicted open, ligand binding or closed, nonbinding conformations. Transfectants expressing alphaLbeta2 heterodimers containing locked-open but not locked-closed or wild-type I domains constitutively adhered to intercellular adhesion molecule-1 (ICAM-1) substrates. Locking the I domain closed abolished constitutive and activatable adhesion. The isolated locked-open I domain bound as well as the activated alphaLbeta2 heterodimer, and binding was abolished by reduction of the disulfide. Lovastatin, which binds under the conformationally mobile C-terminal alpha-helix of the I domain, inhibited binding to ICAM-1 by alphaLbeta2 with wild-type, but not locked-open I domains. These data establish the importance of conformational change in the alphaL I domain for adhesive function and show that this domain is sufficient for full adhesive activity." @default.
- W2095272173 created "2016-06-24" @default.
- W2095272173 creator A5003615852 @default.
- W2095272173 creator A5016321178 @default.
- W2095272173 creator A5019175017 @default.
- W2095272173 creator A5025363376 @default.
- W2095272173 creator A5041160849 @default.
- W2095272173 creator A5053036995 @default.
- W2095272173 date "2001-02-27" @default.
- W2095272173 modified "2023-10-18" @default.
- W2095272173 title "An isolated, surface-expressed I domain of the integrin αLβ2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond" @default.
- W2095272173 cites W1490451576 @default.
- W2095272173 cites W1492715703 @default.
- W2095272173 cites W1494325196 @default.
- W2095272173 cites W1509156028 @default.
- W2095272173 cites W1546157935 @default.
- W2095272173 cites W1550140963 @default.
- W2095272173 cites W1572472402 @default.
- W2095272173 cites W169876379 @default.
- W2095272173 cites W1762713345 @default.
- W2095272173 cites W1968690892 @default.
- W2095272173 cites W1972470306 @default.
- W2095272173 cites W1995782088 @default.
- W2095272173 cites W2003111769 @default.
- W2095272173 cites W2015313829 @default.
- W2095272173 cites W2017602598 @default.
- W2095272173 cites W2022431638 @default.
- W2095272173 cites W2037986253 @default.
- W2095272173 cites W2039284154 @default.
- W2095272173 cites W2039805883 @default.
- W2095272173 cites W2044831835 @default.
- W2095272173 cites W2060913542 @default.
- W2095272173 cites W2068468264 @default.
- W2095272173 cites W2076397950 @default.
- W2095272173 cites W2089184841 @default.
- W2095272173 cites W2089625435 @default.
- W2095272173 cites W2095430146 @default.
- W2095272173 cites W2099675490 @default.
- W2095272173 cites W2107553760 @default.
- W2095272173 cites W2114774709 @default.
- W2095272173 cites W2120355609 @default.
- W2095272173 cites W2125435732 @default.
- W2095272173 cites W2138408888 @default.
- W2095272173 cites W2140799426 @default.
- W2095272173 cites W2141648369 @default.
- W2095272173 cites W2144954800 @default.
- W2095272173 cites W2162452021 @default.
- W2095272173 cites W2163361020 @default.
- W2095272173 cites W2339616204 @default.
- W2095272173 cites W4239023878 @default.
- W2095272173 cites W4255358151 @default.
- W2095272173 cites W4301891965 @default.
- W2095272173 cites W4302422033 @default.
- W2095272173 doi "https://doi.org/10.1073/pnas.041606398" @default.
- W2095272173 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/30148" @default.
- W2095272173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11226249" @default.
- W2095272173 hasPublicationYear "2001" @default.
- W2095272173 type Work @default.
- W2095272173 sameAs 2095272173 @default.
- W2095272173 citedByCount "128" @default.
- W2095272173 countsByYear W20952721732012 @default.
- W2095272173 countsByYear W20952721732013 @default.
- W2095272173 countsByYear W20952721732014 @default.
- W2095272173 countsByYear W20952721732015 @default.
- W2095272173 countsByYear W20952721732016 @default.
- W2095272173 countsByYear W20952721732017 @default.
- W2095272173 countsByYear W20952721732018 @default.
- W2095272173 countsByYear W20952721732019 @default.
- W2095272173 countsByYear W20952721732020 @default.
- W2095272173 countsByYear W20952721732021 @default.
- W2095272173 countsByYear W20952721732022 @default.
- W2095272173 countsByYear W20952721732023 @default.
- W2095272173 crossrefType "journal-article" @default.
- W2095272173 hasAuthorship W2095272173A5003615852 @default.
- W2095272173 hasAuthorship W2095272173A5016321178 @default.
- W2095272173 hasAuthorship W2095272173A5019175017 @default.
- W2095272173 hasAuthorship W2095272173A5025363376 @default.
- W2095272173 hasAuthorship W2095272173A5041160849 @default.
- W2095272173 hasAuthorship W2095272173A5053036995 @default.
- W2095272173 hasBestOaLocation W20952721731 @default.
- W2095272173 hasConcept C107824862 @default.
- W2095272173 hasConcept C12554922 @default.
- W2095272173 hasConcept C14036430 @default.
- W2095272173 hasConcept C170493617 @default.
- W2095272173 hasConcept C178790620 @default.
- W2095272173 hasConcept C185592680 @default.
- W2095272173 hasConcept C195687474 @default.
- W2095272173 hasConcept C25166345 @default.
- W2095272173 hasConcept C27256138 @default.
- W2095272173 hasConcept C2909375385 @default.
- W2095272173 hasConcept C55493867 @default.
- W2095272173 hasConcept C71240020 @default.
- W2095272173 hasConcept C79879829 @default.
- W2095272173 hasConcept C84416704 @default.
- W2095272173 hasConcept C86803240 @default.
- W2095272173 hasConcept C95444343 @default.
- W2095272173 hasConceptScore W2095272173C107824862 @default.
- W2095272173 hasConceptScore W2095272173C12554922 @default.