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- W2095283609 abstract "The thermoregulatory effects of α-melanocyte stimulating hormone (MSH), its potent analog, [Nle4, D-Phe7]-α-MSH (NDP-MSH), and the 1–7, 4–10, and 7–13 amino acid fragments of NDP-MSH were examined by administering these substances to the anterior hypothalamicpreoptic area (AHPOA) of rats. In experiments 1a (MSH) and 1b (NDP-MSH), animals received 0, 0.5, 1, 5, 10, or 50 pM peptide in 0.5 μl sterile saline (n = 6/group), with core rectal temperatures being recorded 0, 10, 20, 30, 40, 50, and 60 min after injection. In Experiment 2, subjects received 5 pM NDP-MSH1–7, NDP-MSH4–10, NDP-MSH7–13, NDP-MSH, or the vehicle, 0.5 μl sterile saline, in a counterbalanced fashion (n = 13). Results indicated a significant effect of dose for both MSH, F(5, 30) = 2.81, p = 0.03, and NDP-MSH, F(5, 30) = 4.98, p = 0.002. A Newman-Keul's analysis indicated that mean temperatures for all groups receiving MSH or NDP-MSH were significantly greater than for the group that received saline (p < 0.05). An analysis of the data from Experiment 2 indicated a significant effect of substance, F(4, 48) = 17.31, p < 0.001. Mean temperature of animals receiving NDP-MSH, the 4–10, or the 7–13 fragments, did not differ from each other but were significantly greater than mean temperatures for animals receiving sterile saline of the 1–7 fragment of NDP-MSH (p < 0.05)." @default.
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- W2095283609 date "1993-03-01" @default.
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- W2095283609 title "α-Melanocyte-stimulating hormone (MSH) and [Nle4, D-Phe7]-α-MSH: Effects on core temperature in rats" @default.
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- W2095283609 doi "https://doi.org/10.1016/0091-3057(93)90163-n" @default.
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