FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095283721> ?p ?o ?g. }

• W2095283721 abstract "Abstract Background The uptake of particles by actin-powered invagination of the plasma membrane is common to protozoa and to phagocytes involved in the immune response of higher organisms. The question addressed here is how a phagocyte may use geometric cues to optimize force generation for the uptake of a particle. We survey mechanisms that enable a phagocyte to remodel actin organization in response to particles of complex shape. Results Using particles that consist of two lobes separated by a neck, we found that Dictyostelium cells transmit signals concerning the curvature of a surface to the actin system underlying the plasma membrane. Force applied to a concave region can divide a particle in two, allowing engulfment of the portion first encountered. The phagosome membrane that is bent around the concave region is marked by a protein containing an inverse Bin-Amphiphysin-Rvs (I-BAR) domain in combination with an Src homology (SH3) domain, similar to mammalian insulin receptor tyrosine kinase substrate p53. Regulatory proteins enable the phagocyte to switch activities within seconds in response to particle shape. Ras, an inducer of actin polymerization, is activated along the cup surface. Coronin, which limits the lifetime of actin structures, is reversibly recruited to the cup, reflecting a program of actin depolymerization. The various forms of myosin-I are candidate motor proteins for force generation in particle uptake, whereas myosin-II is engaged only in retracting a phagocytic cup after a switch to particle release. Thus, the constriction of a phagocytic cup differs from the contraction of a cleavage furrow in mitosis. Conclusions Phagocytes scan a particle surface for convex and concave regions. By modulating the spatiotemporal pattern of actin organization, they are capable of switching between different modes of interaction with a particle, either arresting at a concave region and applying force in an attempt to sever the particle there, or extending the cup along the particle surface to identify the very end of the object to be ingested. Our data illustrate the flexibility of regulatory mechanisms that are at the phagocyte's disposal in exploring an environment of irregular geometry." @default.
• W2095283721 created "2016-06-24" @default.
• W2095283721 creator A5003504383 @default.
• W2095283721 creator A5011491185 @default.
• W2095283721 creator A5015901663 @default.
• W2095283721 creator A5023885382 @default.
• W2095283721 creator A5024832343 @default.
• W2095283721 creator A5037869457 @default.
• W2095283721 creator A5055573403 @default.
• W2095283721 date "2010-12-01" @default.
• W2095283721 modified "2023-10-17" @default.
• W2095283721 title "Curvature recognition and force generation in phagocytosis" @default.
• W2095283721 cites W1491212708 @default.
• W2095283721 cites W1550374019 @default.
• W2095283721 cites W1555902918 @default.
• W2095283721 cites W1590737147 @default.
• W2095283721 cites W1593755409 @default.
• W2095283721 cites W1808856393 @default.
• W2095283721 cites W1853775877 @default.
• W2095283721 cites W1874401485 @default.
• W2095283721 cites W1928407788 @default.
• W2095283721 cites W1959046849 @default.
• W2095283721 cites W1964145620 @default.
• W2095283721 cites W1970893792 @default.
• W2095283721 cites W1973298030 @default.
• W2095283721 cites W1974857683 @default.
• W2095283721 cites W1977516412 @default.
• W2095283721 cites W1979324769 @default.
• W2095283721 cites W1979513617 @default.
• W2095283721 cites W1979872560 @default.
• W2095283721 cites W1981507681 @default.
• W2095283721 cites W1983769291 @default.
• W2095283721 cites W1986597110 @default.
• W2095283721 cites W1989760629 @default.
• W2095283721 cites W1990044005 @default.
• W2095283721 cites W1991898819 @default.
• W2095283721 cites W1992322222 @default.
• W2095283721 cites W1994788479 @default.
• W2095283721 cites W1995366061 @default.
• W2095283721 cites W1995478242 @default.
• W2095283721 cites W2005966470 @default.
• W2095283721 cites W2015497529 @default.
• W2095283721 cites W2017998270 @default.
• W2095283721 cites W2019304984 @default.
• W2095283721 cites W2022548531 @default.
• W2095283721 cites W2025882607 @default.
• W2095283721 cites W2028170357 @default.
• W2095283721 cites W2049315117 @default.
• W2095283721 cites W2051165421 @default.
• W2095283721 cites W2052626195 @default.
• W2095283721 cites W2056379886 @default.
• W2095283721 cites W2066254967 @default.
• W2095283721 cites W2069314092 @default.
• W2095283721 cites W2071924077 @default.
• W2095283721 cites W2072263383 @default.
• W2095283721 cites W2073584744 @default.
• W2095283721 cites W2081578405 @default.
• W2095283721 cites W2082279421 @default.
• W2095283721 cites W2086845337 @default.
• W2095283721 cites W2092040620 @default.
• W2095283721 cites W2093164707 @default.
• W2095283721 cites W2093373720 @default.
• W2095283721 cites W2095244784 @default.
• W2095283721 cites W2097690118 @default.
• W2095283721 cites W2105802577 @default.
• W2095283721 cites W2114464968 @default.
• W2095283721 cites W2114863423 @default.
• W2095283721 cites W2121333884 @default.
• W2095283721 cites W2126233679 @default.
• W2095283721 cites W2127590113 @default.
• W2095283721 cites W2133170114 @default.
• W2095283721 cites W2133769266 @default.
• W2095283721 cites W2135791967 @default.
• W2095283721 cites W2136613798 @default.
• W2095283721 cites W2140831067 @default.
• W2095283721 cites W2141435123 @default.
• W2095283721 cites W2141921174 @default.
• W2095283721 cites W2146167520 @default.
• W2095283721 cites W2149666707 @default.
• W2095283721 cites W2149745150 @default.
• W2095283721 cites W2155762422 @default.
• W2095283721 cites W2159113211 @default.
• W2095283721 cites W2163519922 @default.
• W2095283721 cites W2163772621 @default.
• W2095283721 cites W2165232829 @default.
• W2095283721 cites W2165448884 @default.
• W2095283721 cites W2167207914 @default.
• W2095283721 cites W2168064391 @default.
• W2095283721 doi "https://doi.org/10.1186/1741-7007-8-154" @default.
• W2095283721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3022777" @default.
• W2095283721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21190565" @default.
• W2095283721 hasPublicationYear "2010" @default.
• W2095283721 type Work @default.
• W2095283721 sameAs 2095283721 @default.
• W2095283721 citedByCount "64" @default.
• W2095283721 countsByYear W20952837212012 @default.
• W2095283721 countsByYear W20952837212013 @default.
• W2095283721 countsByYear W20952837212014 @default.
• W2095283721 countsByYear W20952837212015 @default.
• W2095283721 countsByYear W20952837212016 @default.

• next