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- W2095284177 abstract "Abstract The binding of cis-diamminedichloroplatinum(II) (cis-DDP) to DNA is investigated as a function of the GC content and of the cis-DDP concentration. Analysis of the melting curves and of the UV and CD spectra shows that binding of cis-DDP to DNA is highly sequence specific, GC rich DNAs being destabilized more effectively. At low levels of platination, stabilization of GC- and destabilization of AT-base pairs can be noted. In AT rich DNA, cis- DDP binding favours the B→ A conformational transition. It is also shown that, in addition to specific interactions between cis-DDP and DNA, several non-specific processes take place." @default.
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- W2095284177 date "1991-06-01" @default.
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- W2095284177 title "The dependence of cis-diamminedichloroplatinum(II) binding to DNA upon the GC content: a thermal and spectrophotometrical investigation" @default.
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- W2095284177 doi "https://doi.org/10.1016/s0020-1693(00)83054-6" @default.
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