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- W2095285689 abstract "1- (2,3-dideoxy-β-D-erythro-hexopyranosyl) thymine was used at several positions as nucleoside substitute in the synthesis of oligonucleotides using the H-phosphonate chemistry. A 13-mer with one hexose nucleoside substitution at each end had equivalent hybridization properties as compared to the non-modified 13-mer. However, addition of a second analogue at each end or modification in the middle of a 13-mer caused a sharp decrease in melting temperature. Substitution at the 3′-end with two nucleoside analogues was necessary to withstand the action of snake venom phosphodiesterase." @default.
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- W2095285689 date "2010-09-01" @default.
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- W2095285689 title "Influence of the Incorporation of 1-(2,3-Dideoxy-β-D-Erythro-Hexopyranosyl)-Thymine on the Enzymatic Stability and Base-Pairing Properties of Oligodeoxynucleotides" @default.
- W2095285689 doi "https://doi.org/10.1002/bscb.19921010207" @default.
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