FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2095287442> ?p ?o ?g. }

• W2095287442 endingPage "e1000731" @default.
• W2095287442 startingPage "e1000731" @default.
• W2095287442 abstract "Trypanosomes are parasites that cycle between the insect host (procyclic form) and mammalian host (bloodstream form). These parasites lack conventional transcription regulation, including factors that induce the unfolded protein response (UPR). However, they possess a stress response mechanism, the spliced leader RNA silencing (SLS) pathway. SLS elicits shut-off of spliced leader RNA (SL RNA) transcription by perturbing the binding of the transcription factor tSNAP42 to its cognate promoter, thus eliminating trans-splicing of all mRNAs. Induction of endoplasmic reticulum (ER) stress in procyclic trypanosomes elicits changes in the transcriptome similar to those induced by conventional UPR found in other eukaryotes. The mechanism of up-regulation under ER stress is dependent on differential stabilization of mRNAs. The transcriptome changes are accompanied by ER dilation and elevation in the ER chaperone, BiP. Prolonged ER stress induces SLS pathway. RNAi silencing of SEC63, a factor that participates in protein translocation across the ER membrane, or SEC61, the translocation channel, also induces SLS. Silencing of these genes or prolonged ER stress led to programmed cell death (PCD), evident by exposure of phosphatidyl serine, DNA laddering, increase in reactive oxygen species (ROS) production, increase in cytoplasmic Ca(2+), and decrease in mitochondrial membrane potential, as well as typical morphological changes observed by transmission electron microscopy (TEM). ER stress response is also induced in the bloodstream form and if the stress persists it leads to SLS. We propose that prolonged ER stress induces SLS, which serves as a unique death pathway, replacing the conventional caspase-mediated PCD observed in higher eukaryotes." @default.
• W2095287442 created "2016-06-24" @default.
• W2095287442 creator A5010658149 @default.
• W2095287442 creator A5016857413 @default.
• W2095287442 creator A5047796829 @default.
• W2095287442 creator A5049650069 @default.
• W2095287442 creator A5055144811 @default.
• W2095287442 creator A5087255793 @default.
• W2095287442 date "2010-01-22" @default.
• W2095287442 modified "2023-09-23" @default.
• W2095287442 title "Persistent ER Stress Induces the Spliced Leader RNA Silencing Pathway (SLS), Leading to Programmed Cell Death in Trypanosoma brucei" @default.
• W2095287442 cites W1480948328 @default.
• W2095287442 cites W1500939659 @default.
• W2095287442 cites W1509839595 @default.
• W2095287442 cites W1524970720 @default.
• W2095287442 cites W1528462551 @default.
• W2095287442 cites W1578314153 @default.
• W2095287442 cites W1644794975 @default.
• W2095287442 cites W1751026903 @default.
• W2095287442 cites W181468314 @default.
• W2095287442 cites W1934775191 @default.
• W2095287442 cites W1965556573 @default.
• W2095287442 cites W1966308807 @default.
• W2095287442 cites W1970101659 @default.
• W2095287442 cites W1972482541 @default.
• W2095287442 cites W1973767731 @default.
• W2095287442 cites W1980942517 @default.
• W2095287442 cites W1983909677 @default.
• W2095287442 cites W1986737010 @default.
• W2095287442 cites W1989150820 @default.
• W2095287442 cites W1989722723 @default.
• W2095287442 cites W1991923259 @default.
• W2095287442 cites W1991958238 @default.
• W2095287442 cites W2001589280 @default.
• W2095287442 cites W2005504138 @default.
• W2095287442 cites W2007598683 @default.
• W2095287442 cites W2007630314 @default.
• W2095287442 cites W2009741382 @default.
• W2095287442 cites W2014802525 @default.
• W2095287442 cites W2019520714 @default.
• W2095287442 cites W2019922960 @default.
• W2095287442 cites W2021189028 @default.
• W2095287442 cites W2022255649 @default.
• W2095287442 cites W2025327454 @default.
• W2095287442 cites W2036354940 @default.
• W2095287442 cites W2045893780 @default.
• W2095287442 cites W2048249426 @default.
• W2095287442 cites W2053470799 @default.
• W2095287442 cites W2054159643 @default.
• W2095287442 cites W2054666680 @default.
• W2095287442 cites W2055418337 @default.
• W2095287442 cites W2055836716 @default.
• W2095287442 cites W2057417515 @default.
• W2095287442 cites W2058365603 @default.
• W2095287442 cites W2060574598 @default.
• W2095287442 cites W2064950130 @default.
• W2095287442 cites W2071273959 @default.
• W2095287442 cites W2071780594 @default.
• W2095287442 cites W2075635047 @default.
• W2095287442 cites W2075915930 @default.
• W2095287442 cites W2078027213 @default.
• W2095287442 cites W2081104776 @default.
• W2095287442 cites W2081553037 @default.
• W2095287442 cites W2081731224 @default.
• W2095287442 cites W2089198803 @default.
• W2095287442 cites W2092947800 @default.
• W2095287442 cites W2106314483 @default.
• W2095287442 cites W2108640829 @default.
• W2095287442 cites W2109700867 @default.
• W2095287442 cites W2112816530 @default.
• W2095287442 cites W2114175350 @default.
• W2095287442 cites W2119703543 @default.
• W2095287442 cites W2119803020 @default.
• W2095287442 cites W2127639686 @default.
• W2095287442 cites W2131210945 @default.
• W2095287442 cites W2131387907 @default.
• W2095287442 cites W2136410210 @default.
• W2095287442 cites W2137559575 @default.
• W2095287442 cites W2137755719 @default.
• W2095287442 cites W2138846998 @default.
• W2095287442 cites W2144065739 @default.
• W2095287442 cites W2145294892 @default.
• W2095287442 cites W2148125211 @default.
• W2095287442 cites W2149721868 @default.
• W2095287442 cites W2149967205 @default.
• W2095287442 cites W2153023888 @default.
• W2095287442 cites W2155163967 @default.
• W2095287442 cites W2156559790 @default.
• W2095287442 cites W2157236463 @default.
• W2095287442 cites W2163871305 @default.
• W2095287442 cites W2164390141 @default.
• W2095287442 cites W2166925934 @default.
• W2095287442 cites W2169615432 @default.
• W2095287442 cites W2171895257 @default.
• W2095287442 cites W2328789677 @default.
• W2095287442 cites W2404924867 @default.
• W2095287442 cites W4247632830 @default.
• W2095287442 doi "https://doi.org/10.1371/journal.ppat.1000731" @default.

• next